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GlossaryKeratin 1 (KRT1)

protein providing structural support in skin cells

Keratin 1 (KRT1) is a type of protein found in the outer layer of the skin, playing a crucial role in providing structural integrity and resilience. It partners with Keratin 10 to form intermediate filaments, which help skin cells withstand mechanical stress and prevent damage. Mutations in the KRT1 gene can lead to skin disorders such as epidermolytic hyperkeratosis, characterized by blistering and thickened skin.

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research The Human Type II Keratin Gene Cluster on Chromosome 12q13.13: Final Count or Hidden Secrets?

9 citations , February 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

The document concludes that the human keratin gene cluster is complex, with a need for updated naming to reflect over 50 functional genes important for hair and skin biology.

research Mouse Intestinal Krt15+ Crypt Cells Are Radio-Resistant and Tumor Initiating

33 citations , May 2018 in “Stem Cell Reports”

Krt15+ cells in the mouse intestine resist radiation and can start tumors.

research Large Intragenic KRT1 Deletion Underlying Atypical Autosomal Dominant Keratinopathic Ichthyosis

8 citations , June 2016 in “Journal of Investigative Dermatology”

A rare genetic deletion in the KRT1 gene causes unique skin symptoms in a family.

research Whiskers Amiss: A New Vibrissae and Hair Mutation Near the Krt1 Cluster on Mouse Chromosome 11

7 citations , April 2000 in “Mammalian Genome”

A new mutation in mice causes crooked whiskers and messy hair.

research Novel Mutations of the ABCA12, KRT1 and ST14 Genes in Three Unrelated Newborns Showing Congenital Ichthyosis

6 citations , August 2022 in “The Italian Journal of Pediatrics/Italian journal of pediatrics”

New genetic mutations linked to rare skin disorders were found in three newborns.

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