17 citations
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December 2001 in “Journal of Investigative Dermatology” The osteopontin gene is active in a specific part of rat hair follicles during a certain hair growth phase and might affect hair cycle and diseases.
28 citations
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January 2015 in “Journal of Cell Science” The study demonstrated that the ablation of the PINCH-1 gene in the epidermis of mice led to epidermal detachment, hyperthickening, and progressive hair loss. PINCH-1 deficient keratinocytes exhibited severe adhesion, spreading, and migration defects, more pronounced than those in ILK-deficient keratinocytes, indicating PINCH-1's ILK-independent functions. The research identified EPLIN as a novel PINCH-1 associated protein, which localized to integrin adhesion sites in a PINCH-1-dependent manner. Depletion of EPLIN significantly impaired keratinocyte spreading and migration on collagen and fibronectin. The findings suggested that PINCH-1 regulated integrin-mediated adhesion of keratinocytes through interactions with both ILK and EPLIN.
3 citations
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January 2023 in “American journal of physiology. Cell physiology” Inward rectifier potassium channels are important in many body functions and diseases, and could be potential drug targets.
25 citations
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October 2007 in “Developmental biology” Clim proteins are essential for maintaining healthy corneas and hair follicles.
91 citations
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March 2011 in “Stem Cell Reviews and Reports” Human epidermal neural crest stem cells can become bone and skin pigment cells, making them useful for therapies.