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This study reports the first case in South Korea of Cronkhite-Canada syndrome associated with malignant colon polyp and serrated adenoma.

This review discusses the characteristics and challenges in treating Cronkhite–Canada syndrome but reports no new clinical findings, emphasizing the need for better understanding and uniform treatment approaches.

This case report illustrates that a diagnosis of Cronkhite-Canada syndrome can be made without the presence of polyps, as demonstrated by resolving symptoms with steroid treatment.

Hair loss in Cronkhite-Canada syndrome may be due to an autoimmune response.

In this case report, a patient with Cronkhite-Canada Syndrome developed colon cancer and liver metastasis despite hormone therapy, highlighting the need for regular monitoring and early detection strategies.