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research JAK 1-3 inhibitors and TYK-2 inhibitors in dermatology: Practical pearls for the primary care physician

6 citations , October 2024 in “Journal of Family Medicine and Primary Care”

This systematic review details monitoring and safety guidelines for primary care physicians regarding Janus kinase and tyrosine kinase 2 inhibitors used in treating inflammatory skin conditions, emphasizing their efficacy and the importance of updated knowledge due to associated box warnings and increasing use.

research Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib

184 citations , February 2015 in “EBioMedicine”

This study observed that baricitinib treatment led to significant improvement in a patient's alopecia areata symptoms and suggests further clinical trials to explore its potential as a treatment.

research Efficacy of JAK 1/2 inhibition in the treatment of diffuse non-scarring alopecia due to systemic lupus erythematosus

16 citations , January 2020 in “Annals of the rheumatic diseases”

In this study, baricitinib improved the resolution of arthritis or rash in patients with systemic lupus erythematosus, but outcomes for skin involvement like alopecia were not reported.

research Efficacy and safety of deuruxolitinib, an oral selective Janus kinase 1/2 inhibitor, in adults with alopecia areata: Results from the THRIVE-AA2 Phase 3, randomized, double-blind, controlled trial

2 citations , November 2025 in “Journal of the American Academy of Dermatology”

In this randomized, placebo-controlled trial, adults with severe chronic alopecia areata who received deuruxolitinib showed significant hair regrowth compared to placebo over 24 weeks, and the treatment was generally well-tolerated, though long-term effects remain unexamined.

research Effectiveness and safety of oral Janus kinase inhibitors in patients aged ≤12 with alopecia areata: a systematic review and meta-analysis

March 2026 in “Mendeley Data”

In this systematic review and meta-analysis on participants aged 12 and under with alopecia areata, the authors provide supplementary tables and figures, including pooled outcomes for hair regrowth and safety of oral Janus kinase inhibitors, supporting the main findings on their effectiveness and safety.

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community Been on Fin 1 year and 7 months and 2.5 Oral minoxidil for 6 months

in Is this regrowth? 281 upvotes 1 year ago

The user has been using finasteride for 1 year and 7 months and oral minoxidil for 6 months, noticing peach fuzz that may turn into terminal hair. The user has experienced no side effects and is considering additional treatments like dermarolling and possibly increasing the minoxidil dose.

community can someone help me identify these pls

in Treatment 10 months ago

The user is experiencing diffuse thinning and inflammation despite using 2.5mg dutasteride daily, ciclopirox, and ketoconazole shampoos. They are considering treatments like hydroxychloroquine and JAK inhibitors due to suspected scarring alopecia and have faced challenges in obtaining a scalp biopsy.

community Prolactin the Cause of Hair Loss? ABS-201 the Cure?

29 upvotes 2 months ago

Prolactin may contribute to hair loss, but targeting its receptor won't cure androgenetic alopecia. ABS-201 could be a useful alternative or adjuvant therapy, similar to JAK inhibitors, but not more effective than HMI-115.

community 35M with alopecia areata - Treatments failing, next steps?

in Treatments 127 upvotes 2 months ago

A 35-year-old with alopecia areata has tried finasteride, topical and oral minoxidil, and dutasteride without success in stopping hair loss. The dermatologist suggests JAK inhibitors, but they are too costly, leading to uncertainty about the cause of hair loss.

community The Worst Hair Loss Condition You (MAY) have: LPP

48 upvotes 2 years ago

Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

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Learn

4 / 4 results

learn Baricitinib

JAK inhibitor pill used for severe alopecia areata

learn Neem Oil

Oil from the neem tree, used in traditional remedies

learn Scalp Micropigmentation

How long does Scalp Micropigmentation last, and does it need touch-ups over time? Providers say SMP usually needs a touch-up every 1 to 5 years. It fades but does not fully disappear, and removal needs laser treatment that may be incomplete.

learn Hair Transplant

How long does a hair transplant procedure take? A hair transplant procedure typically takes 4 to 8 hours.
How much does a hair transplant cost? Hair transplant costs typically range from $1,000 to $25,000 depending on various factors.
What is the DHI hair transplant technique? DHI harvests grafts like FUE and implants them with a pen-like tool that makes each small incision and places the graft in one step.
All 4 questions on Hair Transplant →