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      learn Ketoconazole

      antifungal with some anti-androgenic benefits, often used as a shampoo

      learn Bicalutamide

      a nonsteroidal anti-androgen, most commonly used orally for women

      learn Alfatradiol

      a synthetic estrogen used topically as an anti-androgen

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      a topical anti-androgen with less systemic involvement

      learn SCUBE3

      a signaling molecule from dermal papilla cells being actively researched

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      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 7 months ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community It has been 1 year. Should I keep going or give up?

      in Is this regrowth?  6 upvotes 2 months ago
      The user is considering whether to continue their hair loss treatment, which includes finasteride, minoxidil spray, keto shampoo, and dermarolling. Suggestions include increasing minoxidil application, adding multivitamins, improving sleep, and possibly switching to dutasteride, while the consensus is to keep going with the treatment.

      community I have tried many treatments but it's getting worse. 23M.

      in Treatment  90 upvotes 2 months ago
      A 23-year-old male experiencing worsening hair loss has tried topical Minoxidil, Finasteride, Progesterone, Hydrocortisone butyrate, and Ketoconazole. He is considering switching to oral Finasteride due to concerns about side effects and lack of improvement.

      community Topical fin and min and swallowing semen

      in Finasteride/Dutasteride  118 upvotes 9 months ago
      A user asked if it's safe to swallow semen from a partner using topical finasteride and minoxidil. Responses varied, but most suggested it's likely safe, with minimal risk from small amounts of finasteride in semen.