April 2019 in “Journal of Investigative Dermatology” This study observed that simvastatin promoted hair regrowth in a mouse model of alopecia areata by reducing inflammatory markers and T cell proliferation, partly through disruption of isoprenoid metabolite production.
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July 2018 in “Environmental and Experimental Botany” The researchers reported that silencing the NtNCED3-2 gene in tobacco reduced ABA content and drought tolerance, inhibited root and leaf development, and decreased photosynthetic ability due to altered isoprenoid metabolism.
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November 2022 in “Frontiers in Plant Science” This study found that microwave-assisted extraction significantly increased the yield of secondary metabolites, including phenolic and flavonoid content, from Nardostachys jatamansi, enhancing its anti-Alzheimer's potential compared to conventional extraction methods.
July 2025 in “Food Safety and Health” This study used metabolomics to identify distinctive metabolic and phenolic profiles in American ginseng (Panax quinquefolius) from various regions, revealing specific biomarkers that can help differentiate between ginseng from Northeast China, Shandong, and the United States.
This review highlights the potential of plant-derived natural compounds as biocompatible and biodegradable materials in dermal and transdermal delivery systems, emphasizing their unexplored benefits and detailing recent advances in isolation techniques and drug delivery technologies.