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GlossaryIntestinal Stem Cells (ISC)

specialized cells in the gut that regenerate intestinal lining

Intestinal Stem Cells (ISCs) are specialized cells located in the lining of the intestines that have the ability to self-renew and differentiate into various types of cells that make up the intestinal epithelium. These cells are crucial for maintaining the integrity and function of the gut by continuously replenishing the intestinal lining, which is constantly being worn down by digestive processes.

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research Improving Translational Research in Sex-Specific Effects of Comorbidities and Risk Factors in Ischemic Heart Disease and Cardioprotection: Position Paper and Recommendations of the ESC Working Group on Cellular Biology of the Heart

47 citations, May 2020 in “Cardiovascular Research”

The document concludes that future heart disease research should account for sex-specific differences to improve diagnosis, treatment, and outcomes.

[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) Inhibits SCF/c-kit Signaling in 501mel Human Melanoma Cells and Abolishes Melanin Production in Mice and Brownish Guinea Pigs

research [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) Inhibits SCF/c-kit Signaling in 501mel Human Melanoma Cells and Abolishes Melanin Production in Mice and Brownish Guinea Pigs

26 citations, July 2007 in “Biochemical Pharmacology”

ISCK03 stops melanin production in human melanoma cells and lightens skin color in mice and guinea pigs.

research The Role of Oclacitinib in the Management of Ischemic Dermatopathy in Four Dogs

19 citations, April 2019 in “Veterinary dermatology”

Oclacitinib effectively treated a skin condition in dogs that didn't respond to other immunosuppressants.

research Interleukin-6 from Adipose-Derived Stem Cells Promotes Tissue Repair by Increasing Cell Proliferation and Hair Follicles in Ischemia/Reperfusion-Treated Skin Flaps

14 citations, November 2019 in “Mediators of inflammation”

IL-6 from stem cells helps repair skin and grow hair.

Forsythiaside A Protects Against Focal Cerebral Ischemic Injury by Mediating the Activation of the Nrf2 and Endoplasmic Reticulum Stress Pathways

research Forsythiaside A Protects Against Focal Cerebral Ischemic Injury by Mediating the Activation of the Nrf2 and Endoplasmic Reticulum Stress Pathways

12 citations, May 2019 in “Molecular Medicine Reports”

Forsythiaside A helps reduce brain damage from lack of blood flow by activating certain protective pathways.

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community 4 months on min/fin results, very happy with results!

in Progress Pictures 642 upvotes 4 years ago

A user's hair loss progress with Minoxidil and finasteride, with other users questioning the results due to the difference in length between photos.

community Ultrax Labs Hair Surge Caffeine Hair Loss Hair Growth Stimulating Shampoo - For real?

in Question 3 upvotes 8 years ago

The conversation is about the effectiveness of Ultrax Labs Hair Surge Caffeine Hair Loss Hair Growth Stimulating Shampoo, with the original poster questioning if the positive reviews are genuine or not. No specific treatments were discussed.

community Pyrilutamide Phase 3 on its way

in Treatment 129 upvotes 3 years ago

Pyrilutamide Phase 3 approved, starting early 2022 with 416 subjects for 24 weeks. Drug potentially better than RU and Breezula, with some users reporting no side effects.

community Table of the relationship between physical exercise and the regeneration of the deminiaturized hair follicle

in Research/Science 45 upvotes 2 months ago

Exercise, especially leg workouts, combined with finasteride and minoxidil, may enhance hair regrowth. Cold exposure, like cold showers, might further boost results.

community Quit vaping/smoking = 80% less loss

in Research/Science 235 upvotes 8 months ago

Quitting vaping significantly reduced hair loss for a user who was a heavy vaper and also taking finasteride. Some participants suggest nicotine's vasoconstrictive properties may worsen hair loss, while others share personal anecdotes of hair improvement after quitting smoking or vaping.

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