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GlossaryIntegrin β4 (Integrin beta-4)

protein crucial for cell adhesion and skin integrity

Integrin β4 (also known as ITGB4) is a protein that plays a crucial role in cell adhesion, particularly in the skin. It helps anchor cells to the extracellular matrix, which is essential for maintaining the structural integrity of tissues. Mutations in the ITGB4 gene can lead to skin disorders and have been linked to certain types of cancer.

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signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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research Targeting Integrin Pathways: Mechanisms and Advances in Therapy

54 citations , January 2023 in “Signal Transduction and Targeted Therapy”

New therapies are being developed that target integrin pathways to treat various diseases.

research Extracellular Matrix as a Regulator of Epidermal Stem Cell Fate

57 citations , March 2018 in “International Journal of Molecular Sciences”

The extracellular matrix is crucial for controlling skin stem cell behavior and health.

research Leucocyte-Rich Platelet-Rich Plasma Enhances Fibroblast and Extracellular Matrix Activity: Implications in Wound Healing

28 citations , September 2020 in “International Journal of Molecular Sciences”

Leucocyte-rich platelet-rich plasma boosts cell activity and helps wound healing.

research Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem Cells

283 citations , February 2011 in “Cell stem cell”

COL17A1 is crucial for preventing hair graying and loss by supporting hair and pigment stem cells.

research Junctional Epidermolysis Bullosa, Generalized Intermediate Type

January 2015

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