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GlossaryIntegrin β4 (Integrin beta-4)

protein crucial for cell adhesion and skin integrity

Integrin β4 (also known as ITGB4) is a protein that plays a crucial role in cell adhesion, particularly in the skin. It helps anchor cells to the extracellular matrix, which is essential for maintaining the structural integrity of tissues. Mutations in the ITGB4 gene can lead to skin disorders and have been linked to certain types of cancer.

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research Targeting Integrin Pathways: Mechanisms and Advances in Therapy

54 citations, January 2023 in “Signal Transduction and Targeted Therapy”

New therapies are being developed that target integrin pathways to treat various diseases.

research Extracellular Matrix as a Regulator of Epidermal Stem Cell Fate

57 citations, March 2018 in “International Journal of Molecular Sciences”

The extracellular matrix is crucial for controlling skin stem cell behavior and health.

research Australasian Society for Dermatology Research Meeting, May 2007

October 2007 in “Journal of Investigative Dermatology”

The document suggests a bacteria plays a significant role in acne rosacea and that white hair can regain color after transplant, meriting more research on reversing grey hair.

research Molecular Basis for Hair Loss in Mice Carrying a Novel Nonsense Mutation (Hr^rh-R) in the Hairless Gene (Hr)

10 citations, January 2010 in “Veterinary pathology”

A new mutation in the hairless gene causes hair loss and skin wrinkling in mice.

research Mapping the Molecular and Structural Specialization of the Skin Basement Membrane for Inter-Tissue Interactions

2 citations, April 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

The skin's basement membrane is specially designed to support different types of connections between skin layers and hair follicles.

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