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research Endocrine and Intracrine Sources of Androgens in Women: Inhibition of Breast Cancer and Other Roles of Androgens and Their Precursor Dehydroepiandrosterone

515 citations , April 2003 in “Endocrine Reviews”

This review discusses hormone replacement therapy for menopausal women, emphasizing DHEA's unique ability to convert into sex steroids only in targeted tissues, and reports no new clinical results.

Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors

research Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors

402 citations , August 2011 in “Cancer research”

This study found that castration-resistant prostate cancers resistant to CYP17A1 inhibitors may still depend on steroids and could respond to therapies targeting de novo intratumoral steroid synthesis.

research Genes for intermediate filament proteins and the draft sequence of the human genome

287 citations , July 2001 in “Journal of Cell Science”

This study mapped 65 intermediate filament genes in the human genome, highlighting that the majority of keratin-related sequences are inactive pseudogenes, notably for keratins 8 and 18.

Anti-TNF Antibody-Induced Psoriasiform Skin Lesions in Patients with Inflammatory Bowel Disease Are Characterised by Interferon-γ-Expressing Th1 Cells and IL-17A/IL-22-Expressing Th17 Cells and Respond to Anti-IL-12/IL-23 Antibody Treatment

research Anti-TNF antibody-induced psoriasiform skin lesions in patients with inflammatory bowel disease are characterised by interferon-γ-expressing Th1 cells and IL-17A/IL-22-expressing Th17 cells and respond to anti-IL-12/IL-23 antibody treatment

278 citations , March 2013 in “Gut”

In this study, nearly 5% of anti-TNF-treated patients with IBD developed psoriasiform skin lesions, with smoking identified as a main risk factor, and ustekinumab proved highly effective in severe cases.

research Integrin signalling regulates YAP/TAZ to control skin homeostasis

266 citations , January 2016 in “Development”

In this study, researchers found that YAP and TAZ, when localized in the nucleus of basal layer cells, are crucial for skin regeneration and hair growth, with their loss leading to slower cell proliferation, hair loss, and impaired wound healing in mice.

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Community Join

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community Intense hairloss for last 1 year

8 upvotes 3 weeks ago

A 22-year-old is experiencing intense hair loss and has tried minoxidil, finasteride, ketoconazole, and rosemary oil, with rosemary oil helping somewhat. Suggestions include consulting a dermatologist, doing a blood test, and lifestyle changes like diet and exercise.

community INTEGRITY ISSUE - Melissa Toyos Verteporfin Treatment Marketing

14 upvotes 1 month ago

Concerns about the integrity of Dr. Melissa Toyos' marketing for Verteporfin treatment, suggesting photos may be digitally altered. Users express skepticism about the treatment's promotion and results.

community Intermittent fasting triggers hair loss in study (suppresses hair follicle regeneration)

in Research/Science 241 upvotes 8 months ago

Intermittent fasting may suppress hair follicle regeneration, but opinions vary on its impact on hair loss. Some users report no negative effects or even hair improvement while using treatments like finasteride and minoxidil.

community Interpreting pre-finisteride blood panels

2 upvotes 1 year ago

The conversation is about someone planning to start finasteride for hair loss and wanting to interpret pre-treatment blood panels to assess the risk of side effects like gynecomastia. They list various tests to measure hormone levels and other health indicators.

community Interesting study on food supplements in addition to fin/min

in Research/Science 9 upvotes 1 year ago

Adding vitamins like zinc, iron, biotin, and vitamin D to finasteride and minoxidil may help with hair loss. Some users are skeptical about the study's validity due to its precise numbers.

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Learn

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learn Intra-cylane®

learn Selenium

How does Selenium interact with other nutrients like zinc, iron, and vitamin D in supporting hair growth? Selenium supports hair growth by working with zinc, iron, and vitamin D to maintain cellular health.

learn Tea tree

How does tea tree oil interact with the scalp environment in products designed for irritation, dandruff, or mild hair shedding? Tea tree oil helps reduce irritation and dandruff by balancing scalp microbiota and inflammation.

learn Thymosin Beta 4

How is Thymosin Beta 4 typically incorporated into experimental or advanced hair growth products? Thymosin Beta 4 is not an ingredient in any approved or regulated hair-loss product — it is an unapproved research peptide (sold online as TB-500). Published hair studies are in rats and mice only, from one research group; there are no human trials, and the same literature reports it can promote tumour growth.

learn Valproic acid

What is valproic acid, and how did it become a subject of interest in hair growth and alopecia research? Valproic acid is a prescription anticonvulsant that laboratory and mouse studies link to the Wnt/β-catenin hair-growth pathway; one small randomized trial of an 8.3% topical spray reported a hair-count gain over 24 weeks. Oral valproate is also a recognized cause of hair loss and a known teratogen.

learn Hair Transplant

Is there any downtime after a hair transplant? Most patients can return to normal activities within 1 to 3 days after a hair transplant.

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