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Glossary Insulin-like Growth Factor Binding Proteins

regulate insulin-like growth factors' activity and availability

Insulin-like Growth Factor Binding Proteins (IGFBPs) are a group of proteins that bind to insulin-like growth factors (IGFs), which are hormones involved in growth and development. By binding to IGFs, IGFBPs regulate their activity, availability, and interaction with IGF receptors, thereby playing a crucial role in cell growth, differentiation, and metabolism.

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Research

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research Regulation of human dermal papilla cell production of insulin-like growth factor binding protein-3 by retinoic acid, glucocorticoids, and insulin-like growth factor-1

37 citations , June 1996 in “Journal of cellular physiology”

This study found that IGF1, retinoic acid, and dexamethasone increase IGFBP-3 production in cultured human dermal papilla cells, potentially inhibiting IGF1 action on hair growth.

research Vertex balding, plasma insulin-like growth factor 1, and insulin-like growth factor binding protein 3

26 citations , June 2000 in “Journal of The American Academy of Dermatology”

This study found that older men with vertex balding had lower levels of IGFBP-3 and higher levels of IGF-1 in their plasma.

research Vertex balding, plasma insulin-like growth factor 1, and insulin-like growth factor binding protein 3

3 citations , June 2000 in “Journal of The American Academy of Dermatology”

This study found that older men with vertex balding have lower circulating levels of the protein IGFBP-3 and higher levels of IGF-1.

The Association Between Low Circulating Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 with Hair Loss in Women: A Case-Control Study in Basrah, Iraq

research The Association Between Low (Or Reduced) Circulating Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 with Hair Loss in Women. A Case- Control Study in Basrah City of Iraq

July 2026 in “Zenodo (CERN European Organization for Nuclear Research)”

This study found that women with female pattern hair loss had significantly lower serum IGF-1 levels than controls, suggesting a possible role for IGF-1 in this condition.

research The Association Between Low (Or Reduced) Circulating Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 with Hair Loss in Women. A Case- Control Study in Basrah City of Iraq

July 2026 in “Zenodo (CERN European Organization for Nuclear Research)”

This study found that women with female pattern hair loss had significantly lower serum IGF-1 levels compared to controls, but no significant association between IGFBP-3 levels and hair loss severity was observed.

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Community Join

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community Positive Hair Result in Patient using Tirzepatide

4 upvotes 1 year ago

A 57-year-old man with male pattern hair loss and insulin resistance experienced hair regrowth and weight loss after using tirzepatide, without other hair treatments. Dysregulated glucose metabolism is linked to hair loss, with tirzepatide potentially improving hair density by normalizing insulin resistance.

community Creatine is the opposite of minoxidil !

324 upvotes 10 months ago

Creatine may counteract minoxidil's hair growth effects by closing potassium ATP channels, potentially leading to hair loss in predisposed individuals. Despite anecdotal reports, there is no conclusive evidence linking creatine to hair loss.

community Interesting article links major MPB theories to western diet (and life-style)

in Research/Science 58 upvotes 1 year ago

Poor diet and lifestyle contribute to male pattern baldness. Treatments like Minoxidil, dietary changes, and lifestyle adjustments may help slow hair loss.

community 57% increased chance of pattern hair loss independently associated with the consumption of sugary beverages in men (p<0.001).

297 upvotes 2 years ago

Sugary beverages increase the risk of pattern hair loss in men by 57%, and type 2 diabetes is linked to female pattern hair loss. Reducing sugar intake and using treatments like finasteride and minoxidil may help manage hair loss.

community How is dht not beneficial to you?

in Finasteride/Dutasteride 111 upvotes 7 months ago

DHT is important for sexual function and mood, but finasteride and dutasteride can reduce DHT, causing side effects like reduced libido and erectile dysfunction. These treatments are effective for hair loss, but their impact on DHT leads to debate.

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learn Epidermal Growth Factor

learn sh-Polypeptide-7

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learn Metformin

diabetes drug with anti-inflammatory, immunomodulatory, and insulin-sensitizing properties

learn Minoxidil

An essential vasodilator with some anti-androgenic effects

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