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GlossaryImmortalized Cell Line

cells modified to proliferate indefinitely in culture

An immortalized cell line is a population of cells from a multicellular organism that has been modified to proliferate indefinitely in culture. This is achieved by introducing specific genes or by other means that prevent the normal cellular aging process, allowing researchers to study biological processes over extended periods without the cells dying.

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research Peer Review of Establishment of an Immortalized Mouse Dermal Papilla Cell Strain with Optimized Culture Strategy

January 2018

Researchers improved mouse skin cell culture methods and created a similar immortal cell line, but need to clarify their methods and benefits.

research Increased Copy Number of the TERT and TERC Telomerase Subunit Genes in Cancer Cells

145 citations , May 2008 in “Cancer Science”

Cancer cells often have more copies of TERT and TERC genes, which helps them grow and could affect patient outcomes.

research Molecular Regulation of Melanocyte Senescence

85 citations , July 2002 in “Pigment Cell Research”

The article concludes that while we understand a lot about how melanocytes age and how this can prevent cancer, there are still unanswered questions about certain pathways and genes involved.

research Modulation of Genomic and Postgenomic Alterations in Non-Cancer Diseases and Critical Periods of Life

9 citations , October 2008 in “Mutation research”

N-acetyl-L-cysteine (NAC) can prevent DNA damage and protect cells from harm.

research Effect of Decellularized Extracellular Matrix Bioscaffolds Derived from Fibroblasts on Skin Wound Healing and Remodeling

8 citations , June 2022 in “Frontiers in bioengineering and biotechnology”

A patch made from human lung fibroblast material helps heal skin wounds effectively, including diabetic ulcers.

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community Why do we have head hair in first place if we evolved to start losing it in some cases as soon as puberty hits

in Chat 140 upvotes 1 month ago

Hair loss is influenced by genetics and sensitivity to hormones like DHT. Treatments like Minoxidil and finasteride are commonly used, and baldness persists as it doesn't affect reproductive success.

community Pyrilutamide update: three months

in Update 30 upvotes 2 years ago

A user's 3-month experience with pyrilutamide to reduce hair shedding, and how it may not be strong enough to stop the thinning of their hairline. Other users mentioned the effectiveness of minoxidil and finasteride for treating hair loss.

community Pelage, PP405, is creating a database for potential new trial volunteers

in Research/Science 149 upvotes 1 month ago

PP405 is a new hair loss treatment targeting dormant hair follicles, with ongoing trials. Some users consider stopping finasteride and minoxidil to join trials, while others doubt its effectiveness.

community The meds work: my dad at 23 yo vs me at 35 yo

in Finasteride/Dutasteride 1788 upvotes 5 months ago

Finasteride and oral minoxidil effectively maintain a youthful appearance and full head of hair, despite genetic predispositions to balding. The discussion also considers the impact of DHT blockers on masculinity and aging, with lifestyle choices like sunscreen use and a vegetarian diet mentioned.

community Pyrilutamide six month update photos

in Progress Pictures 13 upvotes 2 years ago

A six month update of the users' experience with Pyrilutamide, a hair loss treatment that combines Minoxidil, Finasteride and RU58841.

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