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research 033 IL-15 is an unexpected guardian of hair follicle immune privilege and promotes human hair growth ex vivo

April 2021 in “Journal of Investigative Dermatology”

This study suggests that rather than inhibiting IL-15, selectively stimulating IL-15Ra-mediated signaling could be beneficial for managing alopecia areata and possibly other inflammatory hair loss conditions, as IL-15 promoted hair growth and maintained immune privilege in human hair follicles.

research 013 IL-15/IL-15Rα signaling is a guardian of human hair follicle immune privilege and promotes hair growth

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study reported that IL-15 promotes human hair growth and protects hair follicle immune privilege, potentially stabilizing alopecia areata treatment outcomes when selectively stimulating IL-15Rα signaling.

IL-15 Prolongs Hair Growth and Acts as a Guardian of Human Hair Follicle Immune Privilege

research 056 IL-15 prolongs hair growth and operates as a guardian of human hair follicle immune privilege

July 2022 in “Journal of Investigative Dermatology”

This study suggests that interleukin-15 plays a complex role in alopecia areata, potentially contributing to immune infiltration while also protecting against hair follicle immune privilege collapse and promoting hair growth.

research Interleukin 15 Gene Polymorphism in patients with Alopecia Areata

July 2022 in “The Egyptian Journal of Hospital Medicine”

This study found no significant association between the IL-15 genetic polymorphism (rs17015014) and the risk or severity of Alopecia Areata in the examined population.

Mechanisms of Puerariae Lobatae Radix in Regulating Sebaceous Gland Secretion: Insights from Network Pharmacology and Experimental Validation

research Mechanisms of Puerariae Lobatae Radix in regulating sebaceous gland secretion: insights from network pharmacology and experimental validation

3 citations , July 2024 in “Frontiers in Pharmacology”

This study demonstrates that Puerariae Lobatae Radix may regulate skin lipid metabolism by inhibiting sebaceous gland growth and reducing triglyceride secretion, highlighting its therapeutic potential for sebaceous gland-related conditions.

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community Prolactin the Cause of Hair Loss? ABS-201 the Cure?

29 upvotes 2 months ago

Prolactin may contribute to hair loss, but targeting its receptor won't cure androgenetic alopecia. ABS-201 could be a useful alternative or adjuvant therapy, similar to JAK inhibitors, but not more effective than HMI-115.

community So many horror stories about switching from fin to dut

in Finasteride/Dutasteride 58 upvotes 6 months ago

Switching from finasteride to dutasteride can cause initial shedding, but many see long-term hair regrowth and stabilization. Responses vary, with some experiencing fewer side effects and others finding it less effective.

community M25: Getting way too many DMs, so let’s do this here! AMA about Male Pattern Baldness, Hair Loss, and Products (100% Science-Backed )

1951 upvotes 5 months ago

Finasteride, dutasteride, and minoxidil are discussed as treatments for male pattern baldness. Finasteride and dutasteride are effective DHT blockers, while minoxidil is necessary for regrowth but must be used consistently.

community Finasteride does deplete important nuero-active steroids

11 upvotes 3 years ago

Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.

community Latest study on RU58841 done 19. August 2026.

25 upvotes 3 weeks ago

RU58841 can be absorbed systemically after topical application, but the study did not find immediate hormonal disruption. The study highlights the need for more research on long-term safety and effects of RU58841, as well as the importance of quality control in products from the grey market.

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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