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GlossaryInterleukin-12 (IL12)

protein that activates immune cells to fight infections

Interleukin-12 (IL-12) is a protein produced by certain immune cells that plays a crucial role in regulating the body's immune response. It helps activate natural killer (NK) cells and T cells, which are essential for fighting infections and cancer. IL-12 is also involved in the inflammatory response and can influence the development of autoimmune diseases.

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signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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research Discrimination of Dysplastic Nevi from Common Melanocytic Nevi by Cellular and Molecular Criteria

41 citations , July 2016 in “Journal of Investigative Dermatology”

Dysplastic nevi have unique gene expressions, making them distinct from common melanocytic nevi.

research Case Report: Treatment-Resistant Pityriasis Rubra Pilaris Achieving Remission with Ustekinumab

25 citations , March 2021 in “Australasian Journal of Dermatology”

Ustekinumab successfully treated a man's resistant skin condition when other treatments failed.

research Udenafil Induces the Hair Growth Effect of Adipose-Derived Stem Cells

9 citations , April 2019 in “Biomolecules & Therapeutics”

Udenafil may help hair grow by activating certain stem cells.

research Alopecia Areata Lesions Show Significant Changes In Immune And Keratin Biomarkers That Correlate With Clinical Improvement With Oral Janus Kinase Inhibitors PF-06651600 (JAK3) And PF-06700841 (TYK2/JAK1)

5 citations , April 2019 in “Journal of Investigative Dermatology”

Oral JAK inhibitors improved alopecia areata by modulating immune responses and boosting hair growth.

research Molecular Genetic Dissection of ILVEN Leads to Successful Targeted Therapy

September 2019 in “Journal of Investigative Dermatology”

Targeted therapy with Ustekinumab significantly improved a skin condition called ILVEN, which is caused by mutations in the CARD14 gene.

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