January 2026 in “Journal of Cutaneous Immunology and Allergy” In this case report, a young Japanese man was diagnosed with scalp IgG4-related disease, which mimicked acne keloidalis nuchae but was identified by histopathology and elevated serum IgG4 levels as a systemic fibroinflammatory disorder, highlighting the importance of differential diagnosis in atypical scarring alopecia.
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January 2022 in “Modern Rheumatology Case Reports” This case report details a rare instance of simultaneous onset of systemic lupus erythematosus and IgG4-related disease in a 73-year-old woman, where treatment improved symptoms by using high-dose glucocorticoids, hydroxychloroquine, and belimumab.
This study observed that, among alopecia areata patients in Fujian, China, lower IgG4 levels and higher IFN-γ levels were statistically significant, suggesting their potential role as biomarkers for the condition and highlighting avenues for future therapeutic developments.