2 citations
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January 2023 in “International Journal of Biological Sciences” In this study, miR-221 was identified as a key factor in androgenetic alopecia pathogenesis due to its role in suppressing hair growth by interacting with androgen receptors and affecting related pathways.
January 2022 in “Social Science Research Network” This study found that in androgenetic alopecia, the androgen receptor directly increases miR-221 transcription, which suppresses hair growth by targeting IGF-1 and inactivating specific signaling pathways.
September 2025 in “Current Issues in Molecular Biology” This study highlights IGF-1's role in promoting hair follicle proliferation, vascularization, and growth, suggesting its potential as a treatment target for hair loss disorders like androgenetic alopecia, though more research on delivery methods and long-term effects is needed.
January 2026 in “Stem Cell Research & Therapy” This study found that targeting the AR/miR-128-3p/IGF-1 pathway with ASLNC168501 shows potential for treating androgenetic alopecia by restoring hair follicle stem cell function and promoting hair regeneration.
January 2026 in “Figshare” This study found that the loss of ASLNC168501 accelerates hair follicle stem cell dysfunction in androgenetic alopecia through activation of the AR/miR-128-3p/IGF-1 pathway, suggesting that restoring ASLNC168501 could be a promising therapeutic strategy for hair regeneration.