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    Did you mean Hypoxia-Inducible Factor 1-alpha?
    Glossary Hypoxia-Inducible Factor 1-alpha

    protein that helps cells adapt to low oxygen levels

    Hypoxia-Inducible Factor 1-alpha (HIF-1α) is a protein that helps cells respond to low oxygen levels (hypoxia). It activates various genes that enable cells to adapt to hypoxic conditions, such as those involved in increasing blood supply and altering metabolism. This protein is crucial in processes like wound healing and can also play a role in diseases like cancer, where it can help tumors grow by improving their oxygen supply.

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    1. A combination of pyridine‐2, 4‐dicarboxylic acid diethyl ester and resveratrol stabilizes hypoxia‐inducible factor 1‐alpha and improves hair density in female volunteers International Journal of Cosmetic Science · 2020 · 8 citations
    2. The potential role of hypoxia inducible factor 1 alpha in multipotent germ cells and neural stem/progenitor cells ScholarSpace (University of Hawaii at Manoa) · 2014
    3. Iron Chelators in the Management of Autoimmune-Induced Alopecia: A Focus on Hypoxia-Inducible Factor 1 Modulation and Hair Restoration Journal of Clinical Medicine · 2025
    4. Immunohistochemical Analysis of the Mechanistic Target of Rapamycin and Hypoxia Signalling Pathways in Basal Cell Carcinoma and Trichoepithelioma PloS one · 2014 · 15 citations
    5. KRT17 promotes endometrial cancer cell migration as well as angiogenesis by regulating HIF-1α/VEGF pathway European journal of gynaecological oncology · 2023
    6. Spermidine/spermine-<i>N</i><sup>1</sup>-acetyltransferase: a key metabolic regulator AJP Endocrinology and Metabolism · 2008 · 305 citations
    7. Gene therapy to enhance angiogenesis in chronic wounds Molecular Therapy — Nucleic Acids · 2022 · 36 citations
    8. Scarless wound healing: Transitioning from fetal research to regenerative healing Wiley Interdisciplinary Reviews-Developmental Biology · 2018 · 79 citations
    9. Overexpression of hypoxia-inducible factor-1α in hidradenitis suppurativa: the link between deviated immunity and metabolism Archives of dermatological research · 2023 · 5 citations
    10. Hypoxia inducible factor-1α promotes trichogenic gene expression in human dermal papilla cells Scientific Reports · 2023 · 2 citations
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