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    Did you mean Hypoxia-Inducible Factor 1-alpha?
    Glossary Hypoxia-Inducible Factor 1-alpha

    protein that helps cells adapt to low oxygen levels

    Hypoxia-Inducible Factor 1-alpha (HIF-1α) is a protein that helps cells respond to low oxygen levels (hypoxia). It activates various genes that enable cells to adapt to hypoxic conditions, such as those involved in increasing blood supply and altering metabolism. This protein is crucial in processes like wound healing and can also play a role in diseases like cancer, where it can help tumors grow by improving their oxygen supply.

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    1. A combination of pyridine‐2, 4‐dicarboxylic acid diethyl ester and resveratrol stabilizes hypoxia‐inducible factor 1‐alpha and improves hair density in female volunteers International Journal of Cosmetic Science · 2020 · 8 citations
    2. The potential role of hypoxia inducible factor 1 alpha in multipotent germ cells and neural stem/progenitor cells ScholarSpace (University of Hawaii at Manoa) · 2014
    3. Iron Chelators in the Management of Autoimmune-Induced Alopecia: A Focus on Hypoxia-Inducible Factor 1 Modulation and Hair Restoration Journal of Clinical Medicine · 2025
    4. Immunohistochemical Analysis of the Mechanistic Target of Rapamycin and Hypoxia Signalling Pathways in Basal Cell Carcinoma and Trichoepithelioma PloS one · 2014 · 15 citations
    5. KRT17 promotes endometrial cancer cell migration as well as angiogenesis by regulating HIF-1α/VEGF pathway European journal of gynaecological oncology · 2023
    6. Spermidine/spermine-<i>N</i><sup>1</sup>-acetyltransferase: a key metabolic regulator AJP Endocrinology and Metabolism · 2008 · 305 citations
    7. Gene therapy to enhance angiogenesis in chronic wounds Molecular Therapy — Nucleic Acids · 2022 · 36 citations
    8. Scarless wound healing: Transitioning from fetal research to regenerative healing Wiley Interdisciplinary Reviews-Developmental Biology · 2018 · 79 citations
    9. Overexpression of hypoxia-inducible factor-1α in hidradenitis suppurativa: the link between deviated immunity and metabolism Archives of dermatological research · 2023 · 5 citations
    10. Hypoxia inducible factor-1α promotes trichogenic gene expression in human dermal papilla cells Scientific Reports · 2023 · 2 citations
    11. Insights into male androgenetic alopecia using comparative transcriptome profiling: hypoxia-inducible factor-1 and Wnt/β-catenin signalling pathways British Journal of Dermatology · 2022 · 1 citations
    12. HIF-1α Stimulators Function Equally to Leading Hair Loss Agents in Enhancing Dermal Papilla Growth Skin Pharmacology and Physiology · 2020 · 6 citations
    13. Conditioned media-integrated microneedles for hair regeneration through perifollicular angiogenesis Journal of Controlled Release · 2022 · 12 citations
    14. From Primary MSC Culture of Adipose Tissue to Immortalized Cell Line Producing Cytokines for Potential Use in Regenerative Medicine Therapy or Immunotherapy International Journal of Molecular Sciences · 2021 · 13 citations
    15. Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche Cell stem cell · 2011 · 695 citations
    16. Functional enhancement strategies for immunomodulation of mesenchymal stem cells and their therapeutic application Stem Cell Research & Therapy · 2020 · 53 citations
    17. Hypoxia Treatment of Adipose Mesenchymal Stem Cells Promotes the Growth of Dermal Papilla Cells via HIF-1α and ERK1/2 Signaling Pathways International Journal of Molecular Sciences · 2023 · 1 citations
    18. Epidermal E-Cadherin Dependent β-Catenin Pathway Is Phytochemical Inducible and Accelerates Anagen Hair Cycling Molecular therapy · 2017 · 42 citations
    19. FLCN regulates transferrin receptor 1 transport and iron homeostasis 2021 · 1 citations
    20. An Exploratory In Vivo Study on the Effect of Annurca Apple Extract on Hair Growth in Mice Current Issues in Molecular Biology · 2022 · 1 citations
    21. The Potential of Resveratrol-Rich Peanut Callus Extract in Promoting Hair Growth and Preventing Hair Loss Cosmetics · 2024
    22. Hidradenitis Suppurativa/Acne Inversa/Dissecting Terminal Hair Folliculitis Springer eBooks · 2019 · 1 citations
    23. Hypoxia in Cell Reprogramming and the Epigenetic Regulations Frontiers in Cell and Developmental Biology · 2021 · 36 citations
    24. Understanding human aging and the fundamental cell signaling link in age-related diseases: the middle-aging hypovascularity hypoxia hypothesis Frontiers in Aging · 2023 · 4 citations
    25. Mechanical Stretch Upregulates SDF-1α in Skin Tissue and Induces Migration of Circulating Bone Marrow-Derived Stem Cells into the Expanded Skin Stem Cells · 2013 · 43 citations
    26. Transforming growth factor-β in stem cells and tissue homeostasis Bone Research · 2018 · 245 citations
    27. Wound healing 2012
    28. Hypoxic Preconditioned Nanofat at 1% O2 for 24 h Loses Its Regenerative In Vivo Vascularization Capacity Cells · 2026
    29. Hypoxic Preconditioning Prevents Oxidative Stress-Induced Cell Death in Human Hair Follicle Stem Cells. PubMed · 2024
    30. An Overview of Growth Factors as the Potential Link between Psoriasis and Metabolic Syndrome Journal of Clinical Medicine · 2023 · 6 citations