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GlossaryHypothalamic-Pituitary-Adrenal Axis

regulates stress response through hormone release from brain and adrenal glands

The Hypothalamic-Pituitary-Adrenal (HPA) Axis is a complex network involving the hypothalamus, pituitary gland, and adrenal glands, which work together to regulate the body's response to stress. When you encounter stress, the hypothalamus releases corticotropin-releasing hormone (CRH), prompting the pituitary gland to secrete adrenocorticotropic hormone (ACTH), which in turn stimulates the adrenal glands to produce cortisol, a key stress hormone. This system plays a crucial role in maintaining homeostasis and can impact various bodily functions, including immune response and metabolism.

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research Localized Alopecia and Suppression of Hypothalamic-Pituitary-Adrenal Axis in Dogs Following Treatment with Difluprednate 0.05% Ophthalmic Emulsion

2 citations, December 2021 in “BMC veterinary research”

Long-term use of difluprednate eye drops in dogs can lead to hair loss and hormone imbalance.

research Local Injection of Triamcinolone Acetonide: A Forgotten Etiology of Cushing’s Syndrome

3 citations, January 2017 in “Journal of clinical and diagnostic research”

Injecting steroids like Triamcinolone Acetonide for skin treatments can cause Cushing's Syndrome.

research Sex Differences in the Hypothalamic–Pituitary–Adrenal Axis’ Response to Stress: An Important Role for Gonadal Hormones

197 citations, January 2019 in “Neuropsychopharmacology”

Male and female bodies respond differently to stress, influenced by hormones and development stages, with implications for stress-related diseases.

research Consideration When Interpreting Outpatient Data

May 2011 in “Journal of The American Academy of Dermatology”

Objective assessment is needed to accurately determine medication use and adherence.

research Congenital Adrenal Hyperplasia: Current Insights in Pathophysiology, Diagnostics, and Management

157 citations, May 2021 in “Endocrine Reviews”

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

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community Anyone remember Breezula, the promising hairloss drug that was perpetually 3 years away? Well, it's available right now as an acme treatment. Can we just directly apply to the scalp?

in Treatment 42 upvotes 3 years ago

The conversation discusses the availability of Breezula, a drug for hair loss, now being sold as an acne treatment, and whether it can be applied to the scalp. Users express skepticism about new hair loss treatments and suggest waiting for FDA approval.

community Transient and Permanent Effects of Finasteride Use

in Research/Science 154 upvotes 3 years ago

Potential side effects of 5AR inhibitors like finasteride and dutasteride. Users debate risks, benefits, and personal experiences with these hair loss treatments.

community Mechanism of action of alfatradiol (17 alpha estradiol)

in Research/Science 6 upvotes 5 months ago

The conversation discusses the mechanism of action of alfatradiol (17 alpha estradiol) in treating hair loss. It explores theories that it either inhibits 5 alpha reductase to prevent T->DHT conversion or aromatizes scalp T into 17-alpha-estradiol to save hair.

community How I started reversing Male Pattern Baldness naturally ?

in Question 6 upvotes 7 years ago

The user reversed male pattern baldness using a pro-thyroid diet, lifestyle changes, and scalp stimulation exercises, without Minoxidil or Finasteride. They reported reduced dandruff, itchiness, oiliness, and experienced hair regrowth and thickening over 15 months.

community Ru, Stemoxydine or Alfatradiol? What has your experience been with any of these 3?

in Treatment 3 upvotes 1 year ago

The user is seeking advice on which treatment to add to their current regimen for male pattern baldness. They have previously tried Dutasteride, Nizoral, and oral Minoxidil, but experienced continued hair loss. They are specifically asking for experiences with RU58841, Stemoxydine, or Alfatradiol.

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