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a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor
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research Metabolic Features of the Reproductive Phenotypes of Polycystic Ovary Syndrome
Women with the NIH type of PCOS have more obesity and higher risk of diabetes and heart disease than those with other types of PCOS.
research Metformin Use in Women with Polycystic Ovary Syndrome: Opportunities, Benefits, and Clinical Challenges
Metformin, commonly used for type 2 diabetes, is also prescribed for women with polycystic ovary syndrome (PCOS) to improve insulin resistance, menstrual regularity, and androgen levels, particularly in those with obesity or insulin resistance. While it may enhance fertility when combined with other treatments, it is not effective as a first-line therapy for weight loss, ovulation induction, or treating hyperandrogenic features like hirsutism or acne. During pregnancy, metformin may reduce early pregnancy loss and preterm birth, though its effects on gestational diabetes and preeclampsia are inconsistent. The review highlights the need for more high-quality research to better define the populations that benefit most from metformin and to assess long-term effects on children exposed to it during pregnancy.
research Congenital Adrenal Hyperplasia: Comprehensive Overview and Clinical Management
The document concludes that proper diagnosis and a multidisciplinary approach are crucial for managing Congenital Adrenal Hyperplasia effectively.
research A Unique Case of Isolated Dehydroepiandrosterone-Sulfate Secreting Adrenocortical Carcinoma: A Case Report with Review of the Literature
A woman was diagnosed with a rare adrenal gland cancer that did not show usual hormone-related symptoms.
research Shorter CAG Repeats in the Androgen Receptor Gene May Enhance Hyperandrogenicity in Polycystic Ovary Syndrome
Shorter CAG repeats in a specific gene may increase male hormone activity and symptoms like acne and excess hair in women with PCOS.
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5 / 9 resultscommunity Spironolactine Update: 2 months (34, Female)
A female user's experience using Spironolactone to treat Female Pattern Hair Loss (FPHL) and Androgenic Alopecia, as well as discussing the effectiveness of the drug at different dosages.
community Quit vaping/smoking = 80% less loss
Quitting vaping significantly reduced hair loss for a user who was a heavy vaper and also taking finasteride. Some participants suggest nicotine's vasoconstrictive properties may worsen hair loss, while others share personal anecdotes of hair improvement after quitting smoking or vaping.
community PCOS female who posted before; saw Endo today. prescribed spironolactone and minox 5%
PCOS female visited doctor for hair loss concerns, prescribed spironolactone and minox 5%. Doctor advised against finasteride or dutasteride, user considering self-medication with dutasteride.
community Reflex Hyperandrogenicty: How I recovered from it
The user experienced severe hair shedding from RU58841 and recovered by stopping its use and starting treatments including Minoxidil, Rosemary Verbenone, Stemoxydine, Aminexil, copper peptide serum, and specific shampoos. They also consistently used oral Finasteride and plan to try Minoxidil 10%.
community Proposed new pathogenesis model for androgenetic alopecia (AGA)
The conversation discusses a new model for understanding androgenetic alopecia (AGA), linking it to dietary and lifestyle factors similar to PCOS, and highlighting the role of DHT, vascular damage, and inflammation. Treatments mentioned include Minoxidil, finasteride, and RU58841.