Metformin Use in Women with Polycystic Ovary Syndrome: Opportunities, Benefits, and Clinical Challenges

    May 2025 in “ PubMed ”
    Saeede Saadati, Tamique Mason, Rasoul Godini, Eszter Vanky, Helena Teede, Aya Mousa
    Metformin, commonly used for type 2 diabetes, is also prescribed for women with polycystic ovary syndrome (PCOS) to improve insulin resistance, menstrual regularity, and androgen levels, particularly in those with obesity or insulin resistance. While it may enhance fertility when combined with other treatments, it is not effective as a first-line therapy for weight loss, ovulation induction, or treating hyperandrogenic features like hirsutism or acne. During pregnancy, metformin may reduce early pregnancy loss and preterm birth, though its effects on gestational diabetes and preeclampsia are inconsistent. The review highlights the need for more high-quality research to better define the populations that benefit most from metformin and to assess long-term effects on children exposed to it during pregnancy.
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