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5 / 15 resultslearn GHK-Cu
a copper peptide showing promise in both regrowth and reversing gray hair
learn Melatonin
hormone commonly taken for sleep aid has some topical benefits for hair
learn Valproic acid
an anticonvulsant repurposed for hair loss via histone inhibition
learn Vitamin D
vitamin you should probably be taking for general health might also help your hair a little
Research
5 / 1000+ resultsresearch Novel inhibitors of 5α-reductase
New research is needed to create better drugs that block the enzyme responsible for conditions like male baldness and prostate enlargement.
research Xenobiotica-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models
Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.
research Toll-like Receptor 3 Agonist, Polyinosinic-polycytidylic Acid, Upregulates Carbonic Anhydrase II in Human Keratinocytes
A substance called poly(I:C) increases a protein called carbonic anhydrase II in skin cells, which might help with skin defense and healing.
research The effects of finasteride (Proscar) on hair growth, hair cycle stage, and serum testosterone and dihydrotestosterone in adult male and female stumptail macaques (Macaca arctoides).
Finasteride increases hair growth, prolongs hair cycle, and lowers dihydrotestosterone levels.
research 9 Role of 5α-reductase in health and disease
5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.
Community Join
5 / 680 resultscommunity Has anyone ever used grape seed extract? Any negative effects on hair ?
The conversation is about the effects of grape seed extract on hair, with mixed experiences reported. One user advises against using it.
community Dutasteride is my last Hope ??
User tried topical and oral finasteride and oral minoxidil for hair loss without success. ButterscotchSea3159 suggests using Dutasteride, oral minoxidil, ketoconazole shampoo, microneedling, and possibly RU for better results.
community Study shows further evidence that finasteride and dutasteride take 12-18 months or more to show significant results. Do NOT give up early
The conversation discusses the effectiveness of finasteride and dutasteride in treating hair loss, emphasizing that significant results often take 12-18 months or more. Dutasteride is generally considered superior, with similar or fewer side effects than finasteride, but patience is required for noticeable improvement.
community ‘ Health Risks Associated with Long-Term Finasteride and Dutasteride Use: It’s Time to Sound the Alarm’ Thoughts? Concerns?
The potential health risks associated with long-term use of finasteride and dutasteride, with some responses pointing out the low quality of the journal that published the review article as well as highlighting other alternatives such as keto or minoxidil, and RU58841.
community FCE 28260: A Forgotten 5α-Reductase Inhibition
FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.