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New research is needed to create better drugs that block the enzyme responsible for conditions like male baldness and prostate enlargement.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

A substance called poly(I:C) increases a protein called carbonic anhydrase II in skin cells, which might help with skin defense and healing.

Finasteride increases hair growth, prolongs hair cycle, and lowers dihydrotestosterone levels.

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

Finasteride effectively inhibits 5α reductase, while plant extracts like Permixon and Bazoton don't show significant results.

Some plants with flavonoids may help treat hair loss and promote hair growth.

Massaging the scalp with a cosmetic containing certain natural inhibitors can significantly regrow hair in men with pattern baldness.

Bendamustine combined with rituximab is an effective and well-tolerated treatment for certain types of lymphoma.

Steroidogenic isoenzymes may help improve treatments for common hair loss.

Foreskin keratinocytes and SVK14 cells express certain cytochrome P450 enzymes, unlike hair follicle keratinocytes.

Finasteride potentially treats hair loss by reducing DHT production.

High levels of testosterone and 5α-DHT can lead to cell death in cells important for hair growth.

The enzyme that changes testosterone to a stronger form is mostly found in the part of the hair follicle called the dermal papilla.

Dihydrotestosterone increases growth and spread of human brain cancer cells, and blocking its formation might help treat this cancer.

Androgens play a key role in hair growth and disorders like baldness and excessive hairiness.

Sebocytes play a key role in controlling androgen levels in human skin.

The study found that two enzymes linked to hair loss are located in different parts of the scalp, supporting a common treatment's effectiveness.

A substance called compound-1 could help increase hair growth by maintaining prostaglandin levels in hair follicles.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Erbium glass laser treatment may help with skin remodeling, reduce inflammation, and improve skin cell maturation.

A new method was created to test the effectiveness of Dihydrotestosterone (DHT) inhibitors, like finasteride and dutasteride, in human and fish cells. The results showed fish cells are more sensitive to these treatments, and dutasteride works better than finasteride in all tested cells.

Human skin acts like a hormone-producing organ, making and managing various hormones important for skin and hair health.

We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.

Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.

Avicequinone C, a compound found in the Avicennia marina plant, can reduce hair loss by inhibiting a hormone linked to androgenic alopecia.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

Finasteride shows promise for treating hair loss and excessive hair growth, but more research is needed to confirm its effectiveness and safety.

A gene called BMAL1 plays a role in controlling hair growth.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.