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Glossary High Mobility Group Box 1

protein involved in DNA regulation and immune response signaling

High Mobility Group Box 1 (HMGB1) is a protein that plays a crucial role in regulating DNA structure and function. It is involved in various cellular processes, including DNA repair, transcription, and inflammation. HMGB1 can act as a signaling molecule outside the cell, where it can trigger immune responses and is often associated with inflammatory diseases and tissue damage.

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research Investigating Alopecia Areata and its Connection to The High-Mobility Group Box 1: Review Article

October 2021 in “The Egyptian Journal of Hospital Medicine”

This article discusses the characteristics of alopecia areata, including its reversible hair loss pattern and uncertain causes, but reports no new clinical findings.

Double-Stranded RNA Induces Inflammation via the NF-κB Pathway and Inflammasome Activation in the Outer Root Sheath Cells of Hair Follicles

research Double-stranded RNA induces inflammation via the NF-κB pathway and inflammasome activation in the outer root sheath cells of hair follicles

22 citations , March 2017 in “Scientific reports”

This study investigated the role of NLRP3 inflammasomes in alopecia areata and found that outer root sheath cells may contribute to inflammation by increasing IL-1β and HMGB1 secretion when stimulated with double-stranded RNA.

research HMGB1 promotes hair growth via the modulation of prostaglandin metabolism

12 citations , April 2019 in “Scientific Reports”

This study found that HMGB1 enhanced hair growth by stimulating PGE2 production in human dermal papilla cells, suggesting a potential therapeutic target for alopecia treatment.

research RAGE and Its Ligands in Melanoma

1 citations , April 2015 in “InTech eBooks”

RAGE is a potential target for melanoma treatment, but its effectiveness is uncertain due to variable expression levels.

research The incidence of diplopia following coronal and translid orbital decompression in Graves' orbitopathy

65 citations , September 1998 in “Eye”

This study observed that 19% of patients with Graves' orbitopathy experienced induced diplopia after orbital decompression, with high patient satisfaction reported following both coronal and translid approaches.

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community Fresh off the press: Dutasteride may cause chronic infertility

in Research/Science 643 upvotes 1 year ago

Dutasteride may cause chronic infertility by reducing semen volume and motility, with concerns about irreversible prostate fibrosis. Users consider switching to finasteride or using treatments like minoxidil and microneedling, weighing hair preservation against fertility.

community Possible transgenerational effects of finasteride use on male offspring? (STUDY)

in Research/Science 27 upvotes 4 months ago

Finasteride may affect male offspring's fertility and hormonal balance, with debates on whether to discontinue use before conception. Some users report no issues, while others highlight the high doses used in rat studies.

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41
SMP Specialist
Corey Box
Melbourne, VIC, Australia
1+ yrs

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