This study found that HMGB1 enhanced hair growth by stimulating PGE2 production in human dermal papilla cells, suggesting a potential therapeutic target for alopecia treatment.
October 2021 in “The Egyptian Journal of Hospital Medicine”
This article discusses the characteristics of alopecia areata, including its reversible hair loss pattern and uncertain causes, but reports no new clinical findings.
This study investigated the role of NLRP3 inflammasomes in alopecia areata and found that outer root sheath cells may contribute to inflammation by increasing IL-1β and HMGB1 secretion when stimulated with double-stranded RNA.
87 citations
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September 2019 in “Nature Communications”
In this study, researchers identified that upon tissue injury in a mouse model, epidermal cells at the wound edge convert to an embryonic-like state with SOX11 and SOX4 playing a central role in modulating epidermal development and cell migration genes.