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5 / 1000+ resultsresearch Hereditary 1,25-Dihydroxyvitamin D Resistant Rickets Due to a Mutation Causing Multiple Defects in Vitamin D Receptor Function
A specific gene mutation causes vitamin D resistance, but certain vitamin D analogs might help.
research Hereditary 1,25-Dihydroxyvitamin D-Resistant Rickets With Alopecia Resulting From a Novel Missense Mutation in the DNA-Binding Domain of the Vitamin D Receptor
This study investigated a young boy with hereditary vitamin D resistant rickets (HVDRR) and partial alopecia, identifying a novel missense mutation in the vitamin D receptor (VDR) gene. The mutation, V26M, was found in the DNA-binding domain of the VDR, leading to resistance to the active hormone 1,25-dihydroxyvitamin D3. Despite normal binding and expression of the mutant VDR, the patient's fibroblasts were unresponsive to high concentrations of the hormone, failing to induce CYP24A1 gene expression. The boy's condition improved with intravenous calcium therapy, normalizing his serum chemistries and bone X-rays. This mutation disrupted VDR's ability to bind to a vitamin D response element, explaining the clinical features observed.
research Hereditary 1,25-Dihydroxyvitamin D-Resistant Rickets Due to an Opal Mutation Causing Premature Termination of the Vitamin D Receptor
A specific gene mutation causes vitamin D-resistant rickets and hair loss.
research Hereditary 1,25-Dihydroxyvitamin D-Resistant Rickets in a Pomeranian Dog Caused by a Novel Mutation in the Vitamin D Receptor Gene
A Pomeranian dog had rickets due to a new gene mutation, leading to severe symptoms and euthanasia.
research Hereditary 1,25-Dihydroxyvitamin D-Resistant Rickets
HVDRR is caused by VDR gene mutations, leading to vitamin D resistance, treatable with high calcium doses, but alopecia remains permanent.
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5 / 73 resultscommunity My Theory Regarding a Cause and Cure for Androgenetic Alopecia
Hair loss theory suggests imbalance between Vitamin D Receptor (VDR) and Androgen Receptor (AR) activation. Proposed treatment includes upregulating VDR, downregulating AR, and improving mitochondrial health.
community 5.5 months (Min 2 times /fin 1.25 1 time) daily //derma 1 every week some supplement and Sometimes I use ketoquinazole shampoo The real results from the beginning of the tenth image. 23 y
The user experienced improved hair growth using Minoxidil twice daily, finasteride 1.25mg once daily, weekly dermarolling, supplements, and occasional ketoconazole shampoo for 5.5 months, but noticed hair shedding again after switching types of Minoxidil. Despite returning to the original Minoxidil, the user's hair condition worsened and shedding continued.
community 2.5 Months Into Treatment for Hereditary Hair Loss – Before & After
A man in his twenties with hereditary hair loss has been using 5% Minoxidil, a derma roller, Vitamin D3, and recently started Finasteride, noticing baby hairs and some improvement. Users encourage him, noting good progress and potential for further improvement.
community 22M results after 1 year of fin 1.25mg/day
A user's results after using finasteride (1.25mg/day) for one year, which included improvements to their hair and skin as well as some side effects such as decreased libido and watery semen. They also mentioned they stopped taking creatine around the same time.
community Need Advice on My Hair Regrowth – Baby Hairs Showing Up!
A man in his twenties experiencing hereditary hair loss has been using 5% Minoxidil, a derma roller, Vitamin D3, and recently started Finasteride. He has noticed baby hairs appearing, indicating some regrowth, and is advised to continue the treatment consistently for several months to potentially see significant results.