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Research

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research Improving translational research in sex-specific effects of comorbidities and risk factors in ischaemic heart disease and cardioprotection: position paper and recommendations of the ESC Working Group on Cellular Biology of the Heart

47 citations , May 2020 in “Cardiovascular Research”

This review explores how sex differences influence the pathophysiology, incidence, and treatment outcomes of ischaemic heart disease, and emphasizes the need for more sex-specific research.

research Ex Vivo Assessment of Heat and Humidity Effects on Human Skin and Potential Protection by Kombucha Tea Extract

May 2026 in “Cosmetics”

This study used an ex vivo human skin model to show that tropical conditions disrupt skin homeostasis, resulting in epidermal thickening and junctional flattening, and found that Kombucha tea extract may help preserve skin structure under such stress.

research Forensic approach in cases of anabolic-androgenic steroid abuse and cardiovascular mortality: insights from autopsy, histopathology, immunohistochemistry and toxicology

1 citations , October 2025 in “Frontiers in Cardiovascular Medicine”

This review examines AAS-related deaths and finds that anabolic-androgenic steroid abuse may lead to severe cardiac abnormalities, contributing to fatal arrhythmias and sudden cardiac death in young athletes and bodybuilders.

research Safety of testosterone use in women

49 citations , February 2009 in “Maturitas”

This review discusses the use of testosterone therapy for low libido in women, noting mixed evidence on breast cancer risk and a lack of long-term safety data.

research Topical olive oil with downregulation of stress factors protects mice skin from precarious 3600 MHz electromagnetic radiation.

March 2020 in “The Egyptian Journal of Histology”

This study found that topical olive oil may protect mice skin from damage caused by electromagnetic radiation, particularly when applied before exposure, by mitigating oxidative, inflammatory, and heat shock stress factors.

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Community Join

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community I frequently hear and see people having great regrowth results with RU58841, but I don’t see or hear the same results with Pyrilutamide. Why is this? Or am I wrong?

in Finasteride/Dutasteride 2 upvotes 1 year ago

People have reported hair thickening with Pyrilutamide, particularly using a 1% concentration. Some users are curious about the availability of different concentrations like 0.9%.

community Age 17 August 2025 to Age 18 August 2026

37 upvotes 2 weeks ago

The user has been using finasteride 0.5mg for 10 months and minoxidil inconsistently, noticing hair stabilization and slight thickening. They stopped using heat on their hair, which improved hair health, and experienced initial hair shedding but saw improvement around three months in.

community Thickening up a spot on the crown with S5 cream

3 upvotes 7 years ago

A user discusses helping their brother with hair thinning on the crown by using a laser comb and considering adding S5 spironolactone cream to his regimen, alongside finasteride, which he has used for three years with good results. The conversation mentions that S5 cream is no longer available in the US.

community How to use thickening hair products?

14 upvotes 4 years ago

User asks for advice on using hair thickening products and their order of application. Experienced styler suggests using thickening tonic with a blow dryer, followed by styling powder and clay, then hair fibers, and finishing with hairspray.

community 9 month difference, some decent thickening.

148 upvotes 1 month ago

The user experienced significant hair thickening after 9 months using 2.5mg oral minoxidil and 1mg finasteride daily, with minor side effects like increased body hair. They advise patience with finasteride, noting it can take up to a year to see results.

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Learn

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learn GHK-Cu

Heard alopecia areata leaves scar-like spots? Some peptides are helping those areas regrow hair. Alopecia areata patches usually still have living follicles. Peptides are being studied as a possible add-on, but the evidence is small and early. See a dermatologist for treatment.

learn capsicum

Can the heat from capsicum actually wake up dormant hair follicles? Capsicum heat may stimulate dormant hair follicles through increased blood flow and growth factors.

learn Minoxidil

What are the side effects of minoxidil, and can oral minoxidil affect your heart? Minoxidil can cause side effects, and because it was designed as a blood-pressure drug, some of them involve the heart and circulation. Published studies of low-dose oral minoxidil describe mostly mild problems, but fluid around the heart, pericarditis and other serious events have been reported, and the long-term picture is still being studied. Do not start, stop or change minoxidil without a doctor, and if you develop chest pain, a racing heartbeat, shortness of breath, fainting, swelling or rapid weight gain while using it, stop and seek medical care.

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Clinics

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