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This study describes a protocol for generating hair-bearing skin organoids from human pluripotent stem cells, achieving full complexity resembling fetal skin tissue by day 130 in vitro.

In this study, researchers presented a protocol for generating planar skin organoids from human induced pluripotent stem cells, which include hair follicles and other skin structures, offering a relevant in vitro model for investigating skin physiology, pathogen interactions, and drug responses.

This study found that newborn mouse skin organoids can robustly grow hair in vivo, while adult organoids require specific interventions to restore their hair-forming ability.

This review suggests that self-organizing tissues like organoids could revolutionize material production by enabling sustainable and complex biological systems, such as spider silk glands, to surpass current synthetic designs, though challenges in model species expansion and production scaling remain.

This review discusses the promise of human organoid technology as an alternative to animal models in drug development, highlighting its growing research and commercial potential.