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research Hair shaft miniaturization causes stem cell depletion through mechanosensory signals mediated by a Piezo1-calcium-TNF-α axis

23 citations , October 2021 in “Cell Stem Cell”

This study found that hair shaft miniaturization in aging and genetic hypotrichosis leads to hair follicle stem cell loss through mechanical compression and apoptosis mediated by the Piezo1 channel.

research Pathologic Diagnosis of Central Centrifugal Cicatricial Alopecia on Horizontal Sections

29 citations , September 2014 in “American Journal of Dermatopathology”

This study found that horizontal sections of scalp biopsies in patients with Central Centrifugal Cicatricial Alopecia often reveal follicular miniaturization, inflammation, and scarring, which can guide personalized treatment.

research Bone Morphogenetic Protein Signaling Regulates Postnatal Hair Follicle Differentiation and Cycling

65 citations , September 2004 in “The American journal of pathology”

This study found that overexpressing the BMP inhibitor Noggin in transgenic mice led to a significant loss of nontylotrich hair follicles, suggesting a critical role for BMP signaling in hair follicle morphogenesis and cycling.

research 5α-Reductase: History and Clinical Importance

20 citations , January 2004 in “PubMed Central”

This article reviews the use of 5α-reductase inhibitors for treating benign prostatic hyperplasia, suggesting potential benefits beyond symptom relief, but it reports no new clinical results.

Hair Shaft Abnormalities After Chemotherapy and Tamoxifen Therapy in Patients With Breast Cancer Evaluated by Optical Coherence Tomography

research Hair shaft abnormalities after chemotherapy and tamoxifen therapy in patients with breast cancer evaluated by optical coherence tomography

16 citations , October 2012 in “British Journal of Dermatology”

Chemotherapy can cause significant hair thinning and changes in hair texture, while tamoxifen has a smaller effect.

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Community Join

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community Hair loss research focused on chemistry for decades because we misunderstood the mechanics of growth.

51 upvotes 7 months ago

Hair growth relies on mechanical forces, not just chemicals, with tissue acting like a motor. Minoxidil and finasteride help, but maintaining tissue elasticity and addressing mechanical issues are essential.

community Yo!! One year update chooms!!!!

in Progress Pictures 2858 upvotes 1 year ago

Significant hair regrowth was achieved using 0.5mg oral finasteride, a topical mix of finasteride and minoxidil, and dermastamping. Initial side effects like achy testicles were managed by adjusting the regimen.

community how do you produce more thick white cum while on fin?

in Finasteride/Dutasteride 139 upvotes 5 months ago

Finasteride can reduce semen volume due to prostate shrinkage but doesn't affect fertility. To increase semen volume, consider zinc, lecithin, and reducing finasteride dosage.

community Occipitalis Muscle Tension Theory

13 upvotes 7 months ago

Scalp tension from the occipitalis muscle is theorized to contribute to hair loss, but most believe DHT and genetics are the main causes. Treatments like finasteride and minoxidil are considered more effective than addressing scalp tension.

community Anybody else obsessively searching for pp405 and counting the days?

69 upvotes 1 year ago

People are eagerly awaiting the release of PP405, a new hair loss treatment. Some are using minoxidil and finasteride in the meantime, but there are concerns about scams and unverified products.

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Learn

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learn Cetirizine

How does cetirizine reduce inflammation linked to hair loss? Cetirizine is proposed to lower prostaglandin D2 and raise prostaglandin E2 around hair follicles; three small trials of a compounded 1% topical report modest increases in hair density and shaft thickness, with minoxidil doing better head-to-head. Topical cetirizine is off-label and unapproved for hair loss, and the evidence is too thin to call it effective or safe.

learn Hair Multiplication

extract, clone, and reinsert your own hair cells

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Adenosine

nucleoside used for hair regrowth stimulant properties

learn Valproic acid

an anticonvulsant repurposed for hair loss via histone inhibition

learn Stemoxydine

chemical from L'Oreal that encourages hair to enter growth phase

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Hairo Fallas
Newark, NJ, United States

Hairo Fallas