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research A Temporal Mathematical Model of Alopecia Areata: Investigating Hair Cycle Dynamics and Disease Progression

March 2024 in “Research Square”

This study developed a mathematical model to simulate immune interactions and hair cycle dynamics in alopecia areata, identifying influential factors affecting hair growth and offering insights into potential treatment strategies by targeting immune dysregulation.

research Graft versus host disease presenting as fibrosing alopecia in a pattern distribution: A model for pathophysiological understanding of cicatricial pattern hair loss

9 citations , January 2018 in “International Journal of Trichology”

This case report discusses cutaneous graft versus host disease presenting as fibrosing alopecia, suggesting a mechanistic model for understanding cicatricial pattern hair loss.

research A Comparative Analysis of Large Language Model Accuracy for Image-Based Hair Disease Identification in Diverse Skin Tones

August 2024 in “Journal of the National Medical Association”

ChatGPT is more accurate at diagnosing hair disorders in lighter skin tones than darker ones.

research Therapeutic Potential of Nerve Growth Factor-Modified Hair Follicle Stem Cells Transplantation in a Rat Model of Alzheimer’s Disease

February 2026 in “Journal of Integrative Neuroscience”

In this study, transplantation of hair follicle stem cells and nerve growth factor-modified stem cells significantly reduced amyloid deposition and tau hyperphosphorylation in an Alzheimer's disease rat model, suggesting potential as a treatment option.

research Autoimmune Disease Induction in a Healthy Human Organ: A Humanized Mouse Model of Alopecia Areata

75 citations , October 2012 in “Journal of Investigative Dermatology”

This study developed an animal model that recreates alopecia areata by injecting healthy human skin grafts in immunocompromised mice with peripheral blood mononuclear cells enriched for NKG2D+ and CD56+ cells.

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community Pilose antler extracts promotes hair growth in androgenetic alopecia mice by activating hair follicle stem cells via the AKT and Wnt pathways

11 upvotes 2 years ago

Pilose antler extracts may promote hair growth in androgenetic alopecia by activating hair follicle stem cells through the AKT and Wnt pathways. However, results in mice may not directly apply to humans due to differences in genetic and biochemical conditions.

community Hair loss research is a money grab

227 upvotes 10 months ago

Hair loss is linked to DHT, with treatments like finasteride and minoxidil being common but not definitive. Economic interests influence research, and there is potential for new treatments like PP405 and RU58841.

community Hair loss mental effect is so bad

in Satire 177 upvotes 1 year ago

Hair loss negatively affects mental health, causing anxiety and depression. Minoxidil and finasteride are discussed as treatments, but side effects and mental health concerns remain.

community Researchers working on ways to regenerate lost hair from stem cells identified a recipe for normal hair regeneration in the lab. “A method for cyclical regeneration of hair follicles from hair follicle stem cells and will help make hair follicle regeneration therapy a reality in the near future.”

263 upvotes 5 years ago

Hair loss treatments like finasteride, minoxidil, and hair transplants have side effects and limitations. There is hope for future advancements in stem cell therapy and hair follicle regeneration, though skepticism about their effectiveness and timeline persists.

community Accelerated Hair Loss from Creatine

137 upvotes 11 months ago

Creatine may cause hair loss in some individuals, especially those on finasteride, despite no scientific link. Personal experiences suggest individual sensitivity to DHT could be a factor.

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Learn

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learn Neem Oil

Oil from the neem tree, used in traditional remedies

learn Hair Transplant

When is a hair transplant not possible? A hair transplant is not possible with insufficient donor hair or serious health conditions.
What are the contraindications for hair transplantation? Hair transplantation is not recommended for those with active scalp diseases, insufficient donor hair, or certain medical conditions.

learn Tofacitinib

Why is tofacitinib considered a medical treatment rather than a cosmetic or preventative hair product? Tofacitinib is a prescription JAK inhibitor regulated as a drug, with an FDA boxed warning; its use for alopecia areata is off-label. Studies report regrowth while it is taken, which usually reverses after stopping, so it treats disease activity rather than acting as a cosmetic.

learn Scalp Micropigmentation

Who is a good candidate for scalp micropigmentation? Providers say SMP can suit many kinds of hair loss, but not everyone: active scalp disease, keloid-prone skin, pigment allergy and some medical treatments can rule it out. Get the hair loss diagnosed first.

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