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research Systematic Review—The Potential Implications of Different Platelet-Rich Plasma (PRP) Concentrations in Regenerative Medicine for Tissue Repair

115 citations , August 2020 in “International Journal of Molecular Sciences”

This systematic review indicates that a platelet-rich plasma concentration of 1.0 × 10^6 plt/μL may be optimal for tissue regeneration due to sufficient nutrition supply and effective growth factor diffusion in vivo.

research Module-based complexity formation: periodic patterning in feathers and hairs

47 citations , May 2012 in “Wiley Interdisciplinary Reviews-Developmental Biology”

This article reviews the generation of complex integument patterns through genetic, chemical, and environmental influences, with applications in tissue engineering, but reports no new experimental results.

research Deciphering principles of morphogenesis from temporal and spatial patterns on the integument

19 citations , April 2015 in “Developmental Dynamics”

This study reports that dynamic interactions between stem cells and their niche, influenced by macro-environmental factors, regulate regenerative behavior in integument pattern formation.

Making Waves with Hairs: Genetic and Epigenetic Factors in Hair Pattern Formation

research Making Waves with Hairs

18 citations , April 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

This review explores the potential genetic and epigenetic influences on hair whorl patterns and suggests that pattern formation may involve basic physical-chemical laws, although it reports no new experimental findings.

Feather Arrays Are Patterned by Interacting Signaling and Cell Density Waves

research Feather arrays are patterned by interacting signalling and cell density waves

133 citations , February 2019 in “PLoS Biology”

This research found that feather pattern formation in birds is regulated by a mechanochemical system involving fibroblast growth factor and bone morphogenetic protein signaling, which is altered in the flightless emu and ostrich.

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Community Join

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community Hair loss research focused on chemistry for decades because we misunderstood the mechanics of growth.

51 upvotes 7 months ago

Hair growth relies on mechanical forces, not just chemicals, with tissue acting like a motor. Minoxidil and finasteride help, but maintaining tissue elasticity and addressing mechanical issues are essential.

community Crown growth update ~ 7 months Fin and topical Min

in Progress Pictures 118 upvotes 2 years ago

User shared progress on hair growth after 7 months of using Finasteride and Minoxidil. They hope for thicker hair on the crown.

community Why do some have no change even on nuclear stacks ?

in Research/Science 16 upvotes 2 years ago

Some people see significant hair regrowth using treatments like finasteride and minoxidil, while others experience little to no improvement even with comprehensive treatment plans. Factors such as individual sensitivity to DHT may influence the effectiveness of these hair loss treatments.

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

76 upvotes 2 years ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community He used Dutasteride for 20 years. Interview

113 upvotes 1 year ago

Dutasteride has been used for 20 years with some hair thickness improvement but no dramatic regrowth. The user also experimented with minoxidil, tretinoin, and peptides like BPC 157 for potential benefits in hair density and quality.

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Learn

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learn Epidermal Growth Factor

learn Vascular Endothelial Growth Factor

What is Vascular Endothelial Growth Factor (VEGF), and how does it support hair growth in alopecia? VEGF promotes hair growth by enhancing blood supply to hair follicles.
Can products that stimulate Vascular Endothelial Growth Factor (VEGF) improve blood flow to hair follicles? Yes, products that stimulate VEGF may improve blood flow to hair follicles.
Is Vascular Endothelial Growth Factor (VEGF) available as a topical treatment, or is it only stimulated indirectly? VEGF is not available as a topical treatment for hair loss.
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learn Platelet-Rich Plasma

growth factors taken from your blood and injected into your scalp to stimulate hair

What is Platelet-Derived Growth Factor Beta Polypeptide, and how does it help stimulate new hair growth? PDGF-BB is a growth factor that signals to dermal papilla cells and promotes blood-vessel formation; mouse studies report it can push follicles into the growth phase, and human evidence comes only indirectly from PRP trials. No PDGF product is approved for hair restoration and there is no published human trial of PDGF-BB on its own.

learn Stem Cell Factor

learn Exosomes

Microscopic delivery system that sends growth-promoting signals to hair follicles

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