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GlossaryGremlin

protein inhibiting bone morphogenetic proteins, affecting hair growth

Gremlin is a protein that acts as an antagonist to bone morphogenetic proteins (BMPs), which are involved in various cellular processes including hair follicle development and growth. By inhibiting BMPs, Gremlin can influence hair growth cycles and has been studied for its potential role in conditions like alopecia, where hair loss occurs.

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research Gene Expression Profiling of the Intact Dermal Sheath Cup of Human Hair Follicles

11 citations, January 2018 in “Acta dermato-venereologica”

Researchers found specific genes in the part of hair follicles that could help treat hair disorders.

research Metformin Effects on Blood Levels of Gremlin-1 in Polycystic Ovarian Women

April 2023 in “PubMed”

Metformin lowers gremlin-1 and improves insulin resistance in women with PCOS.

research Colon Cancer Stem Cells: Promise of Targeted Therapy

411 citations, April 2010 in “Gastroenterology”

Targeting colon cancer stem cells might lead to better treatment results.

research Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair

314 citations, April 2010 in “Developmental Cell”

β-catenin in the dermal papilla is crucial for normal hair growth and repair.

$Fibroblasts: Immunomodulatory Factors in Refractory Diabetic Wound Healing$

research Fibroblasts: Immunomodulatory Factors in Refractory Diabetic Wound Healing

20 citations, August 2022 in “Frontiers in Immunology”

Fibroblasts are important in healing diabetic wounds, but high sugar levels can harm their function and slow down the healing process.

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community If RU58841 is such an effective anti androgen

in Research/Science 46 upvotes 11 months ago

RU58841 is discussed as a topical anti-androgen for hair loss, but its effectiveness and safety are not well-documented, leading to mixed opinions and experiences among users. Some combine it with finasteride, but concerns about side effects and lack of FDA approval limit its popularity.

community High DHT with finasteride. Help!

in Finasteride/Dutasteride 6 upvotes 10 months ago

Despite using 5% minoxidil, 0.1% finasteride, and other treatments like microneedling, MK-677, and Cialis, hair loss continues with high testosterone and DHT levels. Considering oral dutasteride but concerned about further increasing testosterone levels.