5 citations
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January 2022 in “Health Science Reports” This study observed that GREM2 was specifically and robustly expressed in the dermal sheath cup of hair follicles during various hair cycle phases, suggesting its significant role in regulating hair cycling processes through BMP signaling.
11 citations
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January 2018 in “Acta dermato-venereologica” In this study, researchers identified gremilin-2 as a highly specific gene to the dermal sheath cup, suggesting it plays a key role in maintaining its properties.
May 2023 in “Journal of Pakistan Medical Association” This study found that women with polycystic ovary syndrome had significantly higher levels of serum and follicular fluid Gremlin-1 compared to healthy controls, suggesting potential diagnostic utility for these biomarker levels.
This study found that metformin treatment significantly decreased gremlin levels and improved insulin resistance in patients with polycystic ovary syndrome.
January 2026 in “Non-coding RNA Research” This study found that low-passage exosomes from dermal papilla cells enhance hair follicle stem cell proliferation and that miR-218-5p may serve as a potential biomarker and therapeutic target for hair growth.