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Did you mean Gorlin-Goltz Syndrome?

GlossaryGorlin Syndrome

genetic disorder causing multiple skin cancers and jaw cysts

Gorlin Syndrome, also known as Nevoid Basal Cell Carcinoma Syndrome (NBCCS), is a genetic disorder characterized by the development of multiple basal cell carcinomas (a type of skin cancer), jaw cysts, and skeletal abnormalities. It is caused by mutations in the PTCH1 gene, which plays a role in cell growth and development. This syndrome can also lead to other health issues, such as developmental delays and an increased risk of other types of tumors.

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research Focal Dermal Hypoplasia Associated With Lymphedema: A Case Report From Saudi Arabia

April 2023 in “Curēus”

A 12-year-old girl in Saudi Arabia with Focal dermal hypoplasia showed skin and dental symptoms, highlighting the condition's variability and the need for personalized treatment.

research Experiences with SMO Antagonist Vismodegib for the Treatment of Locally Advanced Basal Cell Carcinoma

September 2017

Vismodegib effectively treats advanced basal cell carcinoma but requires careful management of serious side effects.

research Androgenetic Alopecia in a Patient with Klinefelter Syndrome: Case Report and Literature Review

December 2020 in “Skin appendage disorders”

Finasteride may effectively treat hair loss in Klinefelter Syndrome patients.

research PTCH1 Germline Mutations and the Basaloid Follicular Hamartoma Values in the Tumor Spectrum of Basal Cell Carcinoma Syndrome

21 citations , January 2018 in “Anticancer Research”

NBCCS and BFHS might be the same syndrome, helping better identify and manage cases.

research Experience with Sonidegib in Patients with Advanced Basal Cell Carcinoma: Case Reports

9 citations , May 2022 in “Drugs in Context”

Sonidegib effectively treated advanced basal cell carcinoma with mild side effects.

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