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GlossaryGlycogen Synthase Kinase 3

enzyme involved in regulating cell functions and signaling pathways

Glycogen Synthase Kinase 3 (GSK-3) is an enzyme that plays a crucial role in various cellular processes, including the regulation of glycogen synthesis, cell division, and cell survival. It is involved in multiple signaling pathways and can influence conditions like diabetes, Alzheimer's disease, and even hair growth by affecting cellular functions and gene expression.

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Escin Activates Canonical Wnt/Beta-Catenin Signaling Pathway by Facilitating the Proteasomal Degradation of Glycogen Synthase Kinase-3 Beta in Cultured Human Dermal Papilla Cells

research Escin Activates Canonical Wnt/Beta-Catenin Signaling Pathway by Facilitating the Proteasomal Degradation of Glycogen Synthase Kinase-3 Beta in Cultured Human Dermal Papilla Cells

July 2023 in “Current Issues in Molecular Biology”

Escin may help treat hair loss by boosting a specific cell growth pathway.

Hair Follicle Stem Cell Differentiation Is Inhibited Through Cross-Talk Between Wnt/β-Catenin and Androgen Signaling in Dermal Papilla Cells From Patients With Androgenetic Alopecia

research Hair Follicle Stem Cell Differentiation Is Inhibited Through Cross-Talk Between Wnt/β-Catenin and Androgen Signaling in Dermal Papilla Cells From Patients With Androgenetic Alopecia

95 citations, May 2012 in “British Journal of Dermatology”

Androgens block hair growth by disrupting cell signals; targeting GSK-3 may help treat hair loss.

Baicalin Increases Hair Follicle Development by Enhancing Canonical Wnt/β-Catenin Signaling and Activating Dermal Papilla Cells in Mice

research Baicalin Increases Hair Follicle Development by Enhancing Canonical Wnt/β-Catenin Signaling and Activating Dermal Papilla Cells in Mice

23 citations, January 2018 in “International Journal of Molecular Medicine”

Baicalin helps hair growth by activating specific cell signals and pathways.

research Effect of Fermented Mackerel Oil on Hair Growth

September 2017 in “Journal of Investigative Dermatology”

Fermented mackerel oil was found to promote hair growth by activating certain cell signals and increasing cell growth.

In Ovo Injection of CHIR-99021 Promotes Feather Follicle Development via Modulating the Wnt Signaling Pathway and Transcriptome in Goose Embryos

research In Ovo Injection of CHIR-99021 Promotes Feather Follicle Development via Modulating the Wnt Signaling Pathway and Transcriptome in Goose Embryos

6 citations, May 2022 in “Frontiers in physiology”

Injecting CHIR-99021 into goose embryos improves feather growth by changing gene activity and energy processes.

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community AGA responded to steroid shots? Biopsy wrong? Please help!

in Female 2 upvotes 6 months ago

A woman with AGA is using spironolactone, dutasteride, finasteride, oral minoxidil, bicalutamide, and anti-androgenic birth control but still experiences worsening hair loss. Steroid shots temporarily stop her hair shedding, leading her to question her biopsy results.

community 57% increased chance of pattern hair loss independently associated with the consumption of sugary beverages in men (p<0.001) Pt 2

in Research/Science 489 upvotes 3 months ago

Sugary beverages increase the risk of pattern hair loss in men by 57%. Treatments discussed include Minoxidil, finasteride, and RU58841.

community 9 month update 1st slide 2020 at my worst vs today. 2nd slide 9 months ago vs today. 3rd, wet hair. 4th, hairline. 5th, damp hair. 6th crown view. 7th, brushed back. 8 & 9, hair in high Summer humidity. 10th, no lighting.

in Progress Pictures 342 upvotes 4 months ago

User shared 9-month hair regrowth progress using a Fin/Min spray from HIMS, with additional microneedling. Other users praised the results and discussed the effectiveness of topical treatments.

community Update about Hair Follicle Glucose Metabolism: New Clinical Data Collection with Ex-President Of American Board Of Hair Restoration Surgery.

in Research/Science 39 upvotes 4 months ago

David Barreto shared that a London-based research group is conducting a 12-month trial for a new nutraceutical treatment for pattern hair loss, designed with Dr. Carlos Puig. The trial aims to provide robust data, with results expected in 1-2 years, potentially representing a significant advancement since finasteride’s introduction in 1997.

community I will have it cured by morning

in Research/Science 370 upvotes 1 year ago

Researching the cause of hair loss and treating it by preventing DHT in the scalp with medication such as finasteride or dutasteride, estrogen, minoxidil, dermarolling, and possible topical antiandrogens.

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