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GlossaryCorticosteroids (Glucocorticoid)

hormones reducing inflammation and immune response, often prescribed for autoimmune diseases

Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex and are used in medicine to reduce inflammation and suppress the immune system. They are commonly prescribed for conditions like asthma, arthritis, and autoimmune diseases, and can be administered in various forms, including oral pills, topical creams, and injections.

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A Novel Point Mutation in the Ligand-Binding Domain of the Human Glucocorticoid Receptor Causing Generalized Glucocorticoid Resistance: The Importance of the C Terminus in Conferring Transactivational Activity

research A Novel Point Mutation in the Ligand-Binding Domain of the Human Glucocorticoid Receptor Causing Generalized Glucocorticoid Resistance: The Importance of the C Terminus in Conferring Transactivational Activity

91 citations, May 2005 in “The Journal of Clinical Endocrinology & Metabolism”

A new mutation in the human glucocorticoid receptor reduces its function and causes resistance to glucocorticoids.

Recent Advances in the Molecular Mechanisms Determining Tissue Sensitivity to Glucocorticoids: Novel Mutations, Circadian Rhythm, and Ligand-Induced Repression of the Human Glucocorticoid Receptor

research Recent Advances in the Molecular Mechanisms Determining Tissue Sensitivity to Glucocorticoids: Novel Mutations, Circadian Rhythm, and Ligand-Induced Repression of the Human Glucocorticoid Receptor

62 citations, August 2014 in “BMC Endocrine Disorders”

New findings explain how genetic changes, body clocks, and certain molecules affect tissue response to stress hormones.

research Primary Generalized Glucocorticoid Resistance And Hypersensitivity

48 citations, January 2011 in “Hormone Research in Paediatrics”

The conclusion is that genetic changes in the glucocorticoid receptor can lead to conditions affecting stress response, immunity, and metabolism, requiring personalized treatment.

research Effect of Thioredoxin Reductase 1 on Glucocorticoid Receptor Activity in Human Outer Root Sheath Cells

34 citations, March 2007 in “Biochemical and Biophysical Research Communications”

Thioredoxin reductase 1 does not affect glucocorticoid receptor activity in hair follicle cells.

Glucocorticoid Receptor Mutants Demonstrate Increased Motility Inside the Nucleus of Living Cells: Time of Fluorescence Recovery After Photobleaching Is an Integrated Measure of Receptor Function

research Glucocorticoid Receptor Mutants Demonstrate Increased Motility Inside the Nucleus of Living Cells: Time of Fluorescence Recovery After Photobleaching Is an Integrated Measure of Receptor Function

31 citations, July 2004 in “Molecular Medicine”

Certain defective glucocorticoid receptor mutants move faster inside cell nuclei and work less effectively.

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community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community AA and Hirsutism but T levels are normal

in Female 8 upvotes 3 years ago

27-year-old female experiences aggressive hair thinning and hirsutism despite normal testosterone levels. Spironolactone and 2% minoxidil were ineffective; high DHEA sulfate levels may be the cause.

community We Need A Solution For The Inflammatory Response related To AGA

in Research/Science 16 upvotes 2 months ago

The conversation is about finding a solution for scalp inflammation related to AGA, with the user expressing frustration that Minoxidil and Finasteride do not address inflammation. The user has researched glucocorticoids and topical NSAIDs for reducing inflammation and seeks advice from specialists.

community Pyrilutamide is working but not strong enough, how long should i wait for noticeable results?

in Update 3 upvotes 1 year ago

User discusses Pyrilutamide's effectiveness for hair loss, needing more time for results. Others suggest waiting 6-12 months and ask about side effects.

community No luck with meds, Check your Cortisol.

in Treatment 32 upvotes 3 months ago

Cortisol from stress can cause hair loss. Controlling cortisol levels improved the effectiveness of finasteride for hair regrowth.

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