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research Global gene expression and comparison between multiple populations in the mouse epidermis

11 citations , June 2016 in “Stem Cell Research”

This study found that a multicolor panel of four surface markers can identify new stem cell populations in mouse hair follicles, providing insights into stem cell diversity and gene expression discrepancies during tissue culture.

research Keratin 17 Impacts Global Gene Expression and Controls G2/M Cell Cycle Transition in Ionizing Radiation–Induced Skin Damage

3 citations , July 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

In this study, researchers found that K17−/− mice suffered more severe hair follicle damage but showed reduced epidermal inflammation after ionizing radiation, with K17's absence leading to aberrant cell cycle progression due to altered p53 genome binding and reduced B-Myb degradation.

research Canonical prolactin signaling and global mRNA expression in the skin of Holstein heifers carrying the SLICK1 allele of the prolactin receptor gene

1 citations , February 2025 in “Journal of Dairy Science”

In this study, researchers found that the SLICK1 allele in cattle may alter local immune regulation, hair growth, and tissue remodeling, as indicated by differential gene expression pathways associated with immune and inflammatory responses in slick vs. nonslick Holsteins.

research Identification of hepatic molecular mechanisms of action of alpha-tocopherol using global gene expression profile analysis in rats

May 2004 in “Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease”

This study found that dietary vitamin E influenced gene expression in rat livers, altering genes related to metabolism, coagulation, and steroid processing, and confirmed its effects on related biological endpoints.

research Global expression profile and global genome methylation signatures in male patients with androgenetic alopecia

2 citations , December 2019 in “Journal of The European Academy of Dermatology and Venereology”

This letter to the editor provides no abstract and reports no new research findings or results.

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Community Join

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community Why does the same hormone grow your beard and destroy your hairline?

44 upvotes 4 months ago

DHT promotes beard growth but causes scalp hair loss due to inflammation and fibrosis. Treatments like finasteride and minoxidil help with hormonal signals and blood flow but don't address underlying inflammation.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 2 years ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Is DHT actually the cause of male pattern hair loss or just a correlating factor? Why I think the research is more complicated than we're told and why I've been looking into GHK-Cu

78 upvotes 4 months ago

DHT is not the only cause of male pattern hair loss; genetic sensitivity, inflammation, and fibrosis also contribute. GHK-Cu, a copper peptide, is being explored as an alternative treatment to finasteride and minoxidil, showing potential in improving follicle health.

community Watching my younger brother bald hurts so much.

in Treatment 265 upvotes 2 years ago

A 19-year-old is distressed about his 17-year-old autistic brother's hair loss, projecting his own insecurities despite being on finasteride and dutasteride. Replies suggest the brother might not care about balding, and the poster should address his own issues.

community If there won't be a cure, is Manchu/Japanese rule our only option?

599 upvotes 3 months ago

The conversation humorously suggests accepting male pattern baldness by adopting historical hairstyles like those of the Manchus and Japanese, rather than hoping for a cure. It also discusses the potential of gene therapy targeting hair loss, despite skepticism about a definitive cure.

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Learn

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Thymosin Beta 4

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