An Out-Of-Lab Trial: A Case Example For The Effect Of Intensive Exercise On Rhythms Of Human Clock Gene Expression

The authors concluded that utilizing clock gene expression from hair follicle cells may improve circadian-phase estimation in clinical settings, aiding the detection of circadian-related sleep problems despite social time constraints.

This study reports a less invasive method for detecting human clock gene expression using hair follicle cells, which accurately reflects individual behavioral rhythms and suggests a time lag issue for rotating shift workers.

This study found that extreme morning and evening chronotypes exhibited significant differences in the timing of circadian clock gene expression in hair follicle cells.

In this study, researchers developed a simple, non-invasive method to monitor circadian gene expression using whole hair root cultures, finding that elderly dementia patients' peripheral clocks still oscillate similarly to younger, healthier individuals, which suggests cellular senescence minimally affects some aspects of circadian rhythms.

This study provides evidence that long-term deregulation of the circadian rhythm in humans affects the regenerative properties of skin and hair precursor cells by altering clock pathway protein expression.