March 2024 in “International journal of molecular sciences” Meibomian glands are highly specialized and differ significantly from other sebaceous glands in structure and function.
27 citations
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July 2018 in “Experimental dermatology” Autophagy is crucial for normal sebaceous gland function and sebum composition.
June 2018 in “Journal of the American Veterinary Medical Association” Three related Persian cats have a rare, likely hereditary skin condition causing hair loss and poor coat quality, with limited treatment options.
53 citations
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February 2015 in “Journal of Investigative Dermatology” The study demonstrated that Ceramide Synthase 4 (CerS4) was crucial for regulating hair follicle stem cell homeostasis and hair follicle cycling in mice. Inactivation of CerS4 led to premature activation of hair follicle bulge stem cells, resulting in prolonged anagen-like states and eventual hair loss in aged mice. This was linked to decreased bone morphogenetic protein (BMP) signaling and increased Wnt signaling, causing changes in hair follicle and sebaceous gland morphology, including increased proliferation and reduced quiescent stem cells. The findings suggested that CerS4 was essential for maintaining normal hair follicle cycling and preventing hair loss by regulating signaling pathways in the epidermis.
71 citations
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November 2005 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” Edar signaling is crucial for proper hair follicle development and function.