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research The effect of chemotherapy regimens in male germ cell tumors on the development of primary hypogonadism

November 2024 in “Scientific Reports”

In this study, researchers at a tertiary cancer center observed that many male germ cell tumor survivors experienced degrees of hypogonadism and erectile dysfunction, highlighting the clinical need to monitor endocrine health in cancer survivors.

research Competitive balance of intrabulge BMP/Wnt signaling reveals a robust gene network ruling stem cell homeostasis and cyclic activation

176 citations , January 2013 in “Proceedings of the National Academy of Sciences”

This study reveals an antagonistic competition between BMP and Wnt signaling within stem cells, influencing their fate towards hair germ characteristics based on the BMP/Wnt activity ratio.

research Single-Cell Transcriptomic Identification of a Proliferative Intermediate State During Early Anagen Hair Follicle Regeneration

August 2026 in “Genes”

This study identified a proliferative intermediate transcriptional state associated with the transition from secondary hair germ cells to lower hair follicle-associated cells during early hair follicle regeneration in mice.

research Hair Follicle Regeneration by Transplantation of a Bioengineered Hair Follicle Germ

6 citations , January 2016 in “Methods in molecular biology”

This protocol describes a method for regenerating hair follicles using a bioengineering technique called the Organ Germ Method, but it reports no new clinical results.

research Androgen levels and apoptosis in the testis during postnatal development of finasteride-treated male rat offspring

10 citations , September 2015 in “Folia Histochemica Et Cytobiologica”

This study found that paternal exposure to finasteride in male rats may impair fertility and affect androgen-sensitive spermatogenesis in their male offspring.

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community Update and new paper from Dr tsuji

26 upvotes 7 years ago

Hair follicle regenerative therapy is being developed, with clinical trials planned in Japan, potentially allowing for hair cloning and eliminating the need for treatments like finasteride. If successful, the treatment could be available in Japan by 2025, but widespread access and affordability may take longer.

community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 3 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

community Nice product I discovered, thought I would share.

in Treatment 456 upvotes 1 year ago

A product that makes hair look thicker and healthier without promoting regrowth. Discussions include treatments like minoxidil, finasteride, red light therapy, and a serum with caffeine and peptides, with mixed effectiveness opinions.

community The new growth in hair loss research: With increasing evidence of its impact on mental health, scientists are pushing forward with breakthroughs on balding. Later this year, scientists will launch one of the first ever clinical trials with hair follicles grown entirely from stem cells.

324 upvotes 7 years ago

Hair loss impacts mental health, with treatments like Minoxidil, finasteride, and stem cell transplants discussed. There is hope for future breakthroughs, but current treatments are limited, and awareness is lacking.

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