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research Azasteroids as Inhibitors of Testosterone 5α-Reductase in Mammalian Skin

34 citations, February 1993 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

Certain 4-azasteroids are effective at blocking the enzyme that processes testosterone in human skin and could help treat acne, excessive hair growth, and male pattern baldness.

Finasteride Inhibits 5α-Reductase Activity in Human Dermal Fibroblasts: Prediction of Its Therapeutic Application in Androgen-Related Skin Diseases

research Finasteride Inhibits 5α-Reductase Activity in Human Dermal Fibroblasts: Prediction of Its Therapeutic Application in Androgen-Related Skin Diseases

3 citations, October 1995 in “International Journal of Dermatology”

Finasteride helps treat skin issues like acne and baldness by blocking testosterone conversion.

research Role of 5α-Reductase in Health and Disease

101 citations, April 1994 in “Baillière's clinical endocrinology and metabolism”

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

research Androgens and Androgen Receptor Action in Skin and Hair Follicles

100 citations, September 2017 in “Molecular and Cellular Endocrinology”

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

research Predominant Expression of 5 Alpha-Reductase Type 1 in Pubic Skin from Normal Subjects and Hirsute Patients

11 citations, May 1996 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

The main enzyme found in pubic skin that could be targeted to treat excessive hair growth is 5 alpha-R2.

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community Topical Finasteride Doesn't Directly Reduce 5ar Enzyme on Scalp

in Finasteride/Dutasteride 72 upvotes 1 year ago

Topical Finasteride doesn't directly reduce 5ar enzyme on scalp and has the same mechanism as oral, needing to go through the liver. Users debate the accuracy of this information and discuss various studies and experiences.

community Fluridil/topilutamide experince

in Treatment 3 upvotes 8 months ago

A user is trying fluridil/topilutamide for hair loss and experiencing side effects like pain in the testicles and genital discomfort. They previously had adverse effects with finasteride, dutasteride, and RU58841, and are considering other treatments like topical dutasteride and spironolactone for maintenance before a hair transplant.

community My Experience with Fin for Young Dudes Like Me

in Finasteride/Dutasteride 10 upvotes 3 years ago

A 19-year-old male shared his negative experience with finasteride, including side effects like vision issues, genital changes, pain, swollen lymph nodes, and mood alterations, which resolved after stopping the medication. He suggests alternative hair loss treatments like exercise, diet, possibly avoiding masturbation, topical anti-androgens, and dermarolling, emphasizing mental health over aesthetics.

community My kid secretly took my avodart what should i do

in Is this regrowth? 42 upvotes 1 month ago

A child accidentally took Avodart, leading to concerns about DHT suppression and its effects. Users humorously discuss potential consequences and treatments like DHT injections and topical solutions.

community 3 months results. 5% min + microneedling. Don't lose hope guys.

in Progress Pictures 189 upvotes 10 months ago

A user shared a 3-month progress picture showing hair regrowth using 5% Minoxidil and microneedling, but not taking Finasteride. Some users are surprised by the quick results, and there's a discussion about the effectiveness of frequent deep microneedling.

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