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signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss
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an anticonvulsant repurposed for hair loss via histone inhibition
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research An Accessible Pharmacodynamic Transcriptional Biomarker for Notch Target Engagement
Hair follicle samples effectively show how well the drug MK-0752 targets and engages with the Notch pathway.
research Dermatologic Toxicities Associated with Chronic Gamma-Secretase Inhibitor Treatment for Desmoid Tumor
Most patients experienced mild to moderate skin problems during a trial for a desmoid tumor treatment.
research Hidradenitis Suppurativa Secondary to Treatment With a Gamma Secretase Inhibitor
A man developed skin lesions as a side effect of a gamma secretase inhibitor used for treating a tumor.
research Transcriptome and Proteome Characterization of Surface Ectoderm Cells Differentiated from Human iPSCs
Blocking TGFβ-RI signaling enhances surface ectoderm differentiation from human stem cells.
research Diagnosis and Treatment of Cutaneous Adverse Effects of Targeted Therapy, Antibody-Drug Conjugates, and Immunotherapy in Cancer Patients: A National Consensus Statement by the Spanish Society of Medical Oncology and the Spanish Academy of Dermatology and Venereology
Early intervention and tailored management are crucial for skin side effects in cancer treatments.
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5 / 27 resultscommunity How ET-02 Works. Also no proof that it's better than Minoxidil. At least for now.
ET-02, a PAI-1 inhibitor, is not proven to be more effective than Minoxidil for hair loss. Other treatments like finasteride, dutasteride, PP405, and AMP-303 are also discussed, focusing on cellular senescence and oxidative stress.
community Coming up to 4 months of minoxidil only 2 weeks of fin
A user experienced significant hair regrowth using minoxidil for four months and recently started finasteride. Suggestions include continuing treatment, possibly shaving for a better look, and adding microneedling to enhance results.
community HLT Megathread on HMI-115 (key takeaways in comments)
HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.
community 35% regrowth brothers and sisters! More effective than Minox and Fin?
A double-blind clinical study that found ingestion of tocotrienols resulted in a 34.5% increase in hair regrowth compared to the placebo group, and discussion about potential side effects and cost of supplementation with vitamin E pills. The conversation noted that it may be more effective than commonly used treatments like minoxidil and finasteride.
community Does Evening primrose oil have a negative effect on a person if they’re taking it alongside finasteride and minoxidil?
A user is concerned about taking evening primrose oil alongside finasteride and minoxidil due to its potential effects on hormonal balance and DHT inhibition. They seek advice on whether to continue the supplement or if their worries are unfounded.