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research Differential sensitivity of epidermal cell subpopulations to β-catenin-induced ectopic hair follicle formation

43 citations , April 2010 in “Developmental Biology”

In this study, researchers observed that the sebaceous gland niche in mice allows for Wnt-induced hair follicle differentiation, unlike the non-permissive bulge.

research Uncertainty and Sensitivity Analysis of Hair Growth Duration in Human Scalp Follicles Under Normal and Alopecic Conditions

June 2026 in “Bulletin of Mathematical Biology”

This study reported that in male subjects with androgenetic alopecia, there is greater uncertainty in hair growth duration, with regulatory factors in the dermal papilla significantly affecting outcomes.

research The Ludwig pattern of androgenetic alopecia is due to a hierarchy of androgen sensitivity within follicular units that leads to selective miniaturization and a reduction in the number of terminal hairs per follicular unit

47 citations , September 2008 in “British Journal of Dermatology”

This study found that women with androgenetic alopecia experience diffuse hair loss due to a decrease in terminal hairs and an increase in vellus hairs per follicular unit.

research Selective Delivery of Tofacitinib Citrate to Hair Follicles Using Lipid-Coated Calcium Carbonate Nanocarrier Controls Chemotherapy-Induced Alopecia Areata

3 citations , May 2023 in “International Journal of Molecular Sciences”

In this study, researchers observed that phospholipid-calcium carbonate hybrid nanoparticles effectively delivered Tofacitinib citrate topically, which significantly inhibited hair follicle apoptosis and promoted hair growth in a mouse model of chemotherapy-induced alopecia, compared to a traditional Tofacitinib solution.

research The Ludwig pattern of androgenetic alopecia is due to a hierarchy of androgen sensitivity within follicular units that leads to selective miniaturization and a reduction in the number of terminal hairs per follicular unit

January 2009 in “The Year book of dermatology”

Ludwig pattern hair loss results from varying androgen sensitivity, causing fewer thick hairs and more thin hairs.

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Community Join

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community Desensitize Follicle Sensitivity to DHT?

12 upvotes 1 month ago

Hair follicles cannot be desensitized to DHT like allergies; treatments focus on reducing DHT levels or blocking its effects using methods like finasteride, GT20029, or PROTACs. Topical treatments like ceterizine and BPA application are also mentioned.

community How is scalp sensitivity even measured?

in Research/Science 9 upvotes 8 months ago

There are no tests to determine genetic follicle sensitivity for hair loss, and conclusions are based on hypothetical or post-balding observations. Finasteride is mentioned as an easy, consistent treatment option compared to natural treatments.

community Another mechanism to hair loss that isn’t talked about. Heavy metals and follicle waste.

16 upvotes 3 months ago

Hair follicles can store waste, potentially leading to hair loss, and treatments like DHT blockers and Minoxidil are suggested. Scalp inflammation and sensitivity to DHT also contribute to hair loss, and addressing these factors with a clinician is recommended.

community Why not move miniaturized hair follicles somewhere else to treat them? Alternative to hair cloning?

4 upvotes 1 year ago

Exploring the idea of transplanting miniaturized hair follicles to healthier areas to potentially reverse hair loss, with concerns about DHT sensitivity and scar tissue formation. The conversation also humorously considers using mice for hair growth experiments.

community Having androgen receptor density and sensitivity at wrong f*ing place

in Satire 7 upvotes 1 year ago

The conversation discusses hair loss treatments, focusing on the use of topical minoxidil, microneedling, finasteride, and dutasteride, while debating the role of testosterone and DHT in hair loss. It also touches on the potential liver health impacts of these treatments and the genetic sensitivity of hair follicles to androgens.

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Learn

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learn Bicalutamide

Nonsteroidal anti-androgen, originally a prostate cancer drug

learn Tretinoin

Vitamin A retinoid cream, prescribed for acne

learn Neem Oil

Oil from the neem tree, used in traditional remedies

learn Niacinamide

Does niacinamide support hair follicle nutrition? Niacinamide is a precursor of NAD+, a molecule cells use for energy. Whether it affects hair follicles in people has not been tested.

learn Scalp Micropigmentation

Will scalp micropigmentation damage my existing hair or follicles? Providers say SMP sits above the hair follicles and does not harm them. No study has tested this, and infection or scarring from any tattoo can affect the skin.

learn Redensyl

Does Redensyl regenerate follicles or only strengthen existing hair? No independent study has shown that Redensyl regenerates follicles or strengthens hair; the only human data are a small, unpublished manufacturer study.

learn Sulforaphane

Can sulforaphane protect hair follicles from inflammation and damage? In lab and mouse studies, sulforaphane reduced markers of inflammation and oxidative stress. No human study has tested whether it protects hair follicles.

learn Fluridil

Can daily Fluridil application stop hair follicle miniaturization? The single published fluridil trial (43 men; placebo-controlled for 3 months, then all on fluridil to 9 months) reported more hairs in the growth phase, but it never measured follicle diameter and has not been replicated — so whether daily use stops miniaturization is unproven, and community users describe stabilization rather than regrowth.

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Clinics

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