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This study found that using a combination of ablative CO₂ fractional laser and fetal fibroblast transplantation significantly reduced scarring in mice, with long-term sphere-forming cultured fibroblasts producing scar appearances closest to normal skin.

In this study, the introduction of autofibroblasts into ischemic wounds was found to be slightly less favorable for regenerative histogenesis compared to a dermal equivalent with heterofibroblasts, with minor differences in epidermis thickness, collagen fiber area, and blood vessel area.

In this study, cryopreserved fibroblast cell sheets cultured on a new substrate showed significantly enhanced healing of cutaneous ulcers in diabetic and immunodeficient mice, suggesting potential effectiveness for refractory skin wounds.

This study found that deleting Snai2 and Snai3 genes in mice disrupts immune cell development, resulting in severe autoimmunity and early death due to the loss of immune tolerance.

This review discusses the differences in wound healing between fetal and adult skin, highlighting the potential to uncover genes for scarless repair that could improve adult wound healing.