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research Natural Product-Inspired Bis(trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies
This study synthesized and evaluated hydroxycinnamate derivatives for their ability to inhibit human SRD5A1, finding that three compounds showed significant inhibitory activity and low cytotoxicity. Compound 10a notably reduced SRD5A1 protein expression in cells, suggesting potential for nonsteroidal treatment of androgen-related conditions.
research HPLC/MS Characterization and Evaluation of the Antioxidant and Anti-Inflammatory Properties of Algerian Medicinal Plant: Carthamus caeruleus L. Extracts
This study found that hydromethanolic extracts from Carthamus caeruleus L. rhizomes exhibited notable antioxidant and anti-inflammatory effects in both in vitro and in vivo experiments, supporting its traditional medicinal uses and suggesting its potential as a source of therapeutic agents.
research Ferulic acid promotes hair growth via estrogen receptor alpha activation in cultured human dermal papilla cells
This study found that Cnidium officinale extract and its compound ferulic acid improved hair growth by promoting dermal papilla cell function and mitochondrial activity, suggesting their potential as a new treatment option for alopecia, possibly through estrogen receptor alpha activation.
research Progress in the design of ascorbic acid derivative-mediated drug delivery
The researchers evaluated scientific data on the usage and pharmaceutical applications of ascorbic acid derivatives, such as ascorbyl-6-palmitate and ascorbyl-2-glucoside, highlighting their development into stable delivery platforms to overcome ascorbic acid's instability and formulation challenges.
research Rice Germ Oil and Ferulic Acid Effects on Hair
This study evaluated a hair mask containing rice germ oil GX-N and ferulic acid on damaged hair and found that rice germ oil GX-N improved hair characteristics after bleaching, UV, and heat exposure, but adding ferulic acid did not provide extra benefits.
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