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research Syndecan-1 Is Required to Maintain Intradermal Fat and Prevent Cold Stress

88 citations , August 2014 in “PLOS genetics”

This study found that mice lacking syndecan-1 experienced cold stress and metabolic issues due to reduced intradermal fat, which was restored by thermoneutral housing or rosiglitazone treatment.

research Negative Impact of Testosterone Deficiency and 5α-Reductase Inhibitors Therapy on Metabolic and Sexual Function in Men

31 citations , January 2017 in “Advances in Experimental Medicine and Biology”

This review discusses the negative health impacts of testosterone deficiency and the potential adverse effects of 5α-reductase inhibitors, emphasizing the need for patient-physician discussions regarding these treatments.

research Rodent models in placental research. Implications for fetal origins of adult disease

7 citations , January 2022 in “Animal Reproduction”

This review examines rodent models to explore how maternal conditions like undernutrition, obesity, hypoxia, and androgen exposure affect fetal programming and metabolic outcomes in offspring, but presents no new clinical findings.

research Parameters of obesity in polycystic ovary syndrome

1 citations , January 2017 in “Journal of rare disease research & treatment”

Obesity is common in PCOS patients and early treatment is important for their heart and metabolic health.

research Genetically Altered Expression of Spermidine/Spermine N1-Acetyltransferase Affects Fat Metabolism in Mice via Acetyl-CoA

128 citations , December 2006 in “Journal of Biological Chemistry”

This study found that overexpression of the enzyme spermidine/spermine N1-acetyltransferase in mice was associated with increased fat oxidation and a leaner phenotype, while knock-out mice exhibited increased fat accumulation.

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community Guys how was your experience with dutestride 0.5mg?

12 upvotes 5 days ago

Dutasteride is used for hair regrowth, with some users experiencing side effects like reduced libido, changes in semen consistency, and emotional effects. Some users report positive hair regrowth results, while others experience issues like gynecomastia and fat accumulation.

community Duasteride and breast tissue accumulation.

4 upvotes 6 months ago

The user is experiencing breast tissue growth from taking dutasteride and minoxidil, and is considering reducing the dosage or stopping the medication. Suggestions include seeing an endocrinologist, using Raloxifene or Arimidex, and considering topical treatments or surgery if necessary.

community Anyone experienced weight gain on dutasteride?

5 upvotes 4 years ago

Dutasteride can lead to increased cholesterol and liver fat. The user is reconsidering its use due to high cholesterol and lipid levels despite a healthy lifestyle.

community My experience with dutasteride 4.5 months and oral minoxidil 1.5 months so far

in Finasteride/Dutasteride 10 upvotes 5 years ago

The user switched from finasteride to dutasteride and added oral minoxidil, which helped regrow their hairline and reduce shedding. They experienced side effects like brain fog, sluggishness, and fat gain with dutasteride, and slight chest tightness with oral minoxidil.

community You NEED this if You’re Taking Fin/Dut

in Finasteride/Dutasteride 1 year ago

DIM is suggested to help with estrogen metabolism for those on finasteride or dutasteride, potentially reversing side effects like fat gain and mood changes. Some users doubt its effectiveness, recommending lifestyle changes or consulting a doctor instead.

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