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research Assessment of Quality of Life and TherapeuticOutcomes of Metformin, Pioglitazone withMyoinositol and Ethinylestradiol Cyproteronein Ethnic Pakistani Women with PolycysticOvary Syndrome

January 2019

In this study, metformin, pioglitazone, and ethinylestradiol cyproterone all improved various clinical features and quality of life in Pakistani women with PCOS, though no drug significantly reduced hirsutism.

research Clinical effectiveness of ethinylestradiol-cyproterone acetate and raloxifene combination therapy in polycystic ovary syndrome-associated infertility

January 2025 in “American Journal of Translational Research”

This study reported that the combination of EE-CPA and raloxifene effectively manages PCOS-related infertility, enhancing pregnancy outcomes through improvements in metabolism, sex hormones, ovarian function, and endometrial receptivity, without significantly increasing adverse effects.

research The use of cyproterone acetate/ethinyl estradiol in hyperandrogenic skin symptoms – a review

11 citations , April 2017 in “The European Journal of Contraception & Reproductive Health Care”

This review highlights that Cyproterone acetate combined with ethinylestradiol is highly effective for treating severe acne and hirsutism in women with hyperandrogenism, and it also provides benefits for cycle control and mood improvement, according to the analysis of 78 studies.

research Effectiveness of Low-dose Ethinylestradiol/Cyproterone Acetate and Ethinylestradiol/Desogestrel with and without Metformin on Hirsutism in Polycystic Ovary Syndrome: A Randomized, Double-blind, Triple-dummy Study.

5 citations , July 2020 in “PubMed”

This study found that EE/CPA and EE/DES were both effective in reducing hirsutism in patients with PCOS, with no additional benefit from adding low-dose metformin.

research The combination of ethinylestradiol/cyproterone acetate is temporarily withdrawn from the market in France. Is the measure justified?

1 citations , March 2013 in “The European Journal of Contraception & Reproductive Health Care”

This publication discusses the political rationale behind the French regulator ANSM's decision to withdraw Diane®-35 from the market, in response to health concerns associated with third-generation oral contraceptives.

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learn Cyproterone

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

Do I need a prescription to take cyproterone? Cyproterone acetate is a prescription-only medicine in every country that licenses it, and it has no FDA approval in the United States — regulators require a prescriber because the drug needs hormonal and liver monitoring and carries a dose-related meningioma risk flagged by the EMA in 2020.
Is cyproterone safe to use during gender transition? Regulators and a large French cohort study link higher-dose, long-term cyproterone acetate to meningioma, and its label also lists liver-enzyme and mood effects — so it is not a drug anyone should call safe in the abstract, and its use in gender-affirming care is a prescriber's decision with monitoring.
Is cyproterone only for women, or can men use it too? Cyproterone acetate is not a women-only drug — published reports describe use in men for prostate cancer, paraphilic disorders and gender-affirming therapy — but it is not FDA-approved for any indication, and European regulators restricted higher doses over a dose-related meningioma risk.
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learn Estradiol

Estrogen hormone, prescribed in tablet, patch and gel forms

learn Ethinylestradiol

learn Ethynylestradiol

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community Does anyone have any experience with Estradiol, Cyproterone Acetate, Spironolactone, Bicalutamide ?

4 upvotes 6 years ago

Some users have experienced good hair regrowth with estradiol, cyproterone acetate, spironolactone, and bicalutamide, but these treatments may cause feminization and other side effects. It's advised to consult a doctor before using these treatments, as they can lower testosterone and have significant risks.

community My Estradiol Level on Finasteride

18 upvotes 1 year ago

Finasteride has no effect on the user's estradiol levels, and body fat may influence aromatization. The user is on testosterone replacement therapy and uses everyday injections to manage high RBC count, with plans to measure DHT, DHEA-S, and pregnenolone levels.

community The lowest cyproterone dose to stop mpb

4 upvotes 3 years ago

The conversation discusses using cyproterone acetate at 12.5 mg to manage hair loss, with concerns about its effects on testosterone and potential health issues. Other treatments mentioned include finasteride, dutasteride, minoxidil, and RU58841, with varying experiences and outcomes.

community Estradiol mesotherapy / idea feedback

5 upvotes 1 year ago

The conversation discusses using estradiol mesotherapy to replicate hormone replacement therapy results while minimizing systemic exposure. It also covers the use of Spironolactone cream, which reportedly has no systemic side effects, and the potential risks of using bicalutamide and Spironolactone in men.

community Cypro to reverse hairloss + Fin?

in Treatment 1 year ago

The conversation discusses using cyproterone temporarily to reverse hair loss, followed by finasteride to maintain regrowth. Concerns about cyproterone's side effects, such as lowering testosterone and potential health risks, are raised, with alternatives like spironolactone suggested for androgen-related issues.

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