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research Estrogens and the skin

137 citations , June 2005 in “Climacteric”

This review indicates that estrogen loss during menopause significantly impacts skin health, while estrogen treatment may increase skin collagen, thickness, and elasticity, though effects on other skin characteristics are inconsistent.

research Gender Differences in Production and Circulating Levels of Sex Hormones and Their Impact on Aging Skin

September 2014 in “Springer eBooks”

This review discusses how sex hormone levels and local steroid synthesis influence gender differences in aging skin, reporting no new clinical results.

research AN ATTEMPT TO ASSESS THE MAGNITUDE OF ENDOGENOUS ANDROGEN PRODUCTION IN A CASE OF THE ADRENOGENITAL SYNDROME*

9 citations , August 1952 in “The Journal of Clinical Endocrinology & Metabolism”

This study describes a method to estimate endogenous hormone production by neutralizing an endogenous hormone with an oppositely acting hormone.

research Effects of Sex Steroid Deprivation/Administration on Hair Growth and Skin Sebum Production in Transsexual Males and Females

176 citations , August 2000 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

In this study, cross-sex hormone therapy affected hair growth patterns differently, with estrogen reducing hair growth in male-to-female transsexuals and testosterone increasing it in female-to-male transsexuals; however, male typical hair diameters were not fully reached in the latter group after 12 months.

research 17β-estradiol Inhibits the Production of RANTES in Human Keratinocytes

56 citations , March 2003 in “Journal of Investigative Dermatology”

This study found that 17β-estradiol inhibited RANTES production in human keratinocytes by suppressing nuclear factor κB activity, suggesting a potential mechanism for 17β-estradiol's modulation of psoriasis-related inflammation.

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Community Join

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community Hypothetically, if estradiol has been a "cure" for hair loss, could one apply estradiol topically and just take an estrogen blocker and/or testosterone to offset the systematic effects?

8 upvotes 1 year ago

Topical estradiol may help with hair loss but can have systemic effects, like reduced testosterone production. Using estrogen blockers can have negative side effects, such as joint pain and reduced sex drive.

community 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?

27 upvotes 1 year ago

Finasteride and dutasteride are discussed for hair loss, with concerns about their effects on neurosteroids and potential side effects like depression. Alternatives like topical estrogen and lifestyle changes are considered, with varying opinions on mental health and hair regrowth.

community 20MTF Results on the crown from 1 year on estrogen injections

468 upvotes 6 months ago

Estrogen injections significantly improved hair growth, particularly on the crown, after stopping finasteride. Monotherapy with estrogen led to hairline improvement, but also caused sterility and potential feminization effects.

community My estrogen levels are obscene

6 upvotes 1 year ago

A 30-year-old male using finasteride for hair loss has high testosterone and estrogen levels but no side effects. He is advised to monitor hormone levels, consider dietary changes, and use additional treatments like vitamin D3, minoxidil, and dutasteride for hair growth.

community My friend is so terrified of balding, he started microdosing estrogen…

in Treatment 1522 upvotes 9 months ago

A person is microdosing estrogen for hair loss after finasteride and dutasteride failed, risking feminizing effects. Alternatives like minoxidil, RU58841, or hair transplants are suggested.

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Learn

3 / 5 results

learn Cyproterone

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

learn Dutasteride

5-alpha reductase inhibitor that blocks both enzyme types, a stronger DHT blocker than finasteride

learn Alfatradiol

Alfatradiol: What does a form of estrogen have to do with hair loss in men? Alfatradiol (17α-estradiol) is a topical hormone sold without prescription in German pharmacies, licensed there for mild androgenetic alopecia, and not FDA-approved. The controlled trial evidence is in women, where hair density and thickness stayed nearly unchanged over 6 months while minoxidil improved them (the trial had no placebo group); no comparable placebo-controlled trial in men appears to have been published.

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