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research Functional analysis of collagen XVII in epithelial cancers and a mouse model

January 2016 in “DOAJ (DOAJ: Directory of Open Access Journals)”

This study demonstrates that collagen XVII is crucial for normal glomerular development, is present in normal colon epithelia, and plays a role in carcinogenesis in colorectal and squamous cell cancers.

Mitochondrial Function in Murine Skin Epithelium Is Crucial for Hair Follicle Morphogenesis and Epithelial-Mesenchymal Interactions

research Mitochondrial Function in Murine Skin Epithelium Is Crucial for Hair Follicle Morphogenesis and Epithelial–Mesenchymal Interactions

56 citations , March 2015 in “Journal of Investigative Dermatology”

Healthy mitochondria in skin cells are essential for proper hair growth and skin cell interaction in mice.

research Epithelial barrier function: assembly and structural features of the cornified cell envelope

425 citations , August 2002 in “BioEssays”

This review discusses the structure and assembly of the cornified cell envelope in stratified squamous epithelial cells and various disorders leading to barrier defects, but reports no new findings.

research 136 Physiological function of Krox20 (Egr2) in epithelial stem cells

April 2021 in “Journal of Investigative Dermatology”

Krox20 is crucial for hair growth and maintaining skin stem cells.

research 448 Physiological function of krox20 (Egr2) in epithelial stem cells

July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

In this study, the researchers reported that Krox20 plays a crucial role in epidermal homeostasis and hair development, influencing stem cell maintenance and cell survival through the modulation of cellular pathways.

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Community Join

5 / 22 results

community Hair cloning breakthrough, this might just be the big one ?

418 upvotes 6 months ago

Japanese scientists discovered ABM cells, enabling successful human hair follicle cloning, potentially curing hair loss. The treatment may be available in Japan by 2028, but it will be expensive and require travel.

community DHT Isn’t the Only Factor in Hair Loss and That Might Be the Key to a Real Cure

373 upvotes 6 months ago

Hair loss involves more than just DHT, with genetic factors like TRPS affecting hair follicles. Treatments such as Amplifica's AMP-601 and AMP-303 target stem cells for potential hair growth solutions.

community Fresh off the press: Dutasteride may cause chronic infertility

in Research/Science 643 upvotes 1 year ago

Dutasteride may cause chronic infertility by reducing semen volume and motility, with concerns about irreversible prostate fibrosis. Users consider switching to finasteride or using treatments like minoxidil and microneedling, weighing hair preservation against fertility.

community Amplifica: Hope or Cope? A Review of Their Pipeline

9 upvotes 1 month ago

Amplifica's AMP-303 showed a modest increase in hair growth, but results were inconsistent and potentially misleading. Hyaluronic acid and osteopontin are being explored for hair growth, with varying effects on different hair types and conditions.

community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 2 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

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Learn

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learn Epidermal Growth Factor

learn Stem Cell Factor

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Beta Polypeptide

learn Overview

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