January 2016 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study demonstrates that collagen XVII is crucial for normal glomerular development, is present in normal colon epithelia, and plays a role in carcinogenesis in colorectal and squamous cell cancers.
56 citations
,
March 2015 in “Journal of Investigative Dermatology” Healthy mitochondria in skin cells are essential for proper hair growth and skin cell interaction in mice.
425 citations
,
August 2002 in “BioEssays” This review discusses the structure and assembly of the cornified cell envelope in stratified squamous epithelial cells and various disorders leading to barrier defects, but reports no new findings.
April 2021 in “Journal of Investigative Dermatology” Krox20 is crucial for hair growth and maintaining skin stem cells.
July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, the researchers reported that Krox20 plays a crucial role in epidermal homeostasis and hair development, influencing stem cell maintenance and cell survival through the modulation of cellular pathways.
252 citations
,
March 1998 in “Developmental dynamics” This study suggests that fibroblast growth factors FGF-4, FGF-8, and FGF-9 may play redundant roles as signals in epithelial-mesenchymal interactions during multiple stages of tooth development in mice.
61 citations
,
July 2011 in “PLOS ONE” This study provides the first direct evidence that spermidine can stimulate hair growth and modulate human epithelial stem cell biology in cultured human hair follicles.
6 citations
,
July 2018 in “Steroids” This study found that testosterone significantly influenced the expression and function of certain ion transporters in the vas deferens, impacting fluid secretion and contributing to a suitable environment for male fertility.
April 2023 in “Journal of Investigative Dermatology” This study found that KROX20 is crucial for hair follicle development and epidermal homeostasis, as its deletion in skin epithelial cells led to hair loss and increased epidermal thickness.
99 citations
,
May 1998 in “Journal of biological chemistry/The Journal of biological chemistry” This study found that small proline-rich proteins modify the biomechanical properties of cornified cell envelopes in rodent forestomachs, potentially affecting the tissue's ability to withstand mechanical stress.
4 citations
,
November 2024 in “Cell Biology and Toxicology” This study suggests that targeting olfactory receptors in the lung epithelium might help treat odorant-induced asthma in cases without type 2 inflammation, as these receptors could play a role in airway sensitivity to smells.
January 2012 in “Infoscience (Ecole Polytechnique Fédérale de Lausanne)” This study demonstrated that the human thymus contains clonogenic thymic epithelial cells capable of self-renewal and maintaining a thymic phenotype in a specific culture system.
102 citations
,
August 2008 in “Genes & Development” This study found that laminin-511 is crucial for hair morphogenesis in mice, as it influences primary cilia formation and dermal papilla maintenance through noggin and sonic hedgehog signaling.
13 citations
,
July 2015 in “Archives of dermatological research” This study found that the spermidine analog N1-methylspermidine prolonged hair follicle growth and decreased inflammation and oxidative stress in cultured hair follicles, suggesting potential relevance for treating inflammatory scalp diseases.
66 citations
,
March 2016 in “Nucleic Acids Research” This study found that Musashi-2 regulates mRNA targets to restrict epithelial cell migration, revealing a key function of Msi2 beyond its known role in promoting cell growth.
7 citations
,
April 2012 in “Biomolecular concepts” This article reviews the role of keratins in epithelial function and structure, discussing their involvement in growth control, organelle functions, and pathomechanisms of disorders, but reports no new clinical results.
45 citations
,
October 2008 in “Cytokine & Growth Factor Reviews” This review discusses the role of activin signaling in hair follicle formation, hair growth cycling, and skin healing, but presents no new clinical findings.
27 citations
,
August 2014 in “Wiley interdisciplinary reviews. Developmental biology” This review highlights similarities in the development of thymus and skin epidermis, reporting no new results; the authors emphasize shared molecular mechanisms despite different embryonic origins.
February 2026 in “Biochemical and Biophysical Research Communications” This study identifies a specific cell population, PDGFRα+/Sca1+/CD34+ mesenchymal cells, which play a crucial role in regenerating hair follicles by promoting the downgrowth phase of the hair cycle, offering insights into organ morphogenesis and stem cell niches essential for adult hair regeneration.
2 citations
,
January 2015 in “Nihon Rinshō Men'eki Gakkai kaishi” This review discusses regenerative therapy approaches, such as tissue stem cell transplantation and gene therapy, for restoring salivary gland function in xerostomia and reports no new research results.
165 citations
,
October 2013 in “Nature Communications” This study demonstrates that bioengineered salivary gland transplants can fully regenerate gland function, producing saliva and restoring normal swallowing in salivary gland-defective mice, offering potential for xerostomia treatment.
137 citations
,
October 2009 in “The American journal of pathology” This study found that matriptase, a membrane serine protease, is crucial for maintaining multiple types of epithelial tissues in mice, with its absence leading to severe organ dysfunction and increased permeability.
38 citations
,
March 2019 in “International Wound Journal” In this study, a new cell-tissue technology using a patient's own skin to create a full-thickness skin autograft successfully treated a chronic wound larger than 200 cm², achieving complete functional skin coverage within 12 weeks and maintaining results at a 6-month follow-up.
38 citations
,
September 2014 in “Cell and Tissue Research” This review explores the infundibulum's role and importance in skin diseases and emphasizes the need for further research into its biology and potential therapeutic targeting, but it presents no new findings.
28 citations
,
December 2015 in “Journal of biological chemistry/The Journal of biological chemistry” This study found that prostasin's proteolytic activity is necessary for normal hair follicle development in mice, but not for interfollicular epidermal development.
9 citations
,
January 2017 in “Elsevier eBooks” This chapter discusses the skin stem cell niche as a complex ecosystem and highlights the diverse components and interactions that influence stem cell function, but it reports no new experimental results.
8 citations
,
March 2019 in “Open Biology” This review describes recent advances in regenerating functional 3D organs from stem cells, particularly ectodermal organs, but reports no new clinical findings and highlights future research directions for organ replacement therapy.
1 citations
,
July 2023 in “Nature communications” This study found that deleting the Mof gene in mouse skin leads to severe defects in skin cell self-renewal, differentiation, and hair follicle growth, indicating that MOF is crucial for mitochondrial and ciliary gene expression and essential for skin development.
April 2023 in “Journal of Investigative Dermatology” This study suggests that MPZL3, a mitochondrially localized protein, may play an integral role in regulating hair follicle cycles, with potential therapeutic implications for hair growth disorders if findings translate to humans.
31 citations
,
November 2022 in “Cold Spring Harbor Perspectives in Biology” This review explores how epithelial cells from various niches in the skin respond and adapt during acute wound repair, highlighting the role of cellular plasticity in reepithelialization and restoring the skin's barrier function.