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research No elevated risk for osteoporosis or osteopenia among women with androgenetic or frontal fribrosing alopecia treated with 5-alpha reductase inhibitors: A retrospective TriNetX cohort study

January 2026 in “Journal of the American Academy of Dermatology”

5-alpha reductase inhibitors do not increase osteoporosis risk in women with certain hair loss conditions.

Increased Incidence of Telogen Effluvium Following Platelet-Rich Plasma Therapy in Patients with Elevated TNF-Alpha Expression: A Prospective Cohort Study

research Increased Incidence of Telogen Effluvium Following Platelet-Rich Plasma Therapy in Patients with Elevated TNF-α Expression: A Prospective Cohort Study

August 2025 in “Research Square (Research Square)”

This study observed that among male patients who experienced telogen effluvium after platelet-rich plasma treatment for androgenic alopecia, there were elevated levels of TNF-α, androgen receptors, and altered 5α-reductase gene expression, suggesting these factors as potential contributors to this unintended outcome.

Secondary Copper Deficiency Associated Dermatitis in Goats: Insights from Hematobiochemical, Mineral and Histopathological Investigation

research Secondary Copper deficiency associated dermatitis in Goats: Insights from hematobiochemical, mineral and histopathological investigation.

August 2026 in “Journal of Livestock Science”

This study identified secondary copper deficiency in Thanjavur black goats as a possible cause of alopecia and other skin issues, despite adequate dietary copper, indicating impaired copper absorption or metabolism.

research THU471 Resolution Of Elevated Alkaline Phosphatase After Joint Replacement In Severe Osteoarthritis

October 2023 in “Journal of the Endocrine Society”

This case report describes ALP elevation in a patient with severe OA that normalized after bilateral knee replacements, highlighting a potential link between OA and ALP levels.

research 3 alpha, 17 beta-androstanediol glucuronide in plasma. A marker of androgen action in idiopathic hirsutism.

179 citations , May 1982 in “The Journal of clinical investigation/The journal of clinical investigation”

This study found that plasma 3 alpha-diol glucuronide was markedly elevated in women with idiopathic hirsutism, suggesting it may be a marker of peripheral androgen action.

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community 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?

27 upvotes 1 year ago

Finasteride and dutasteride are discussed for hair loss, with concerns about their effects on neurosteroids and potential side effects like depression. Alternatives like topical estrogen and lifestyle changes are considered, with varying opinions on mental health and hair regrowth.

community Does anyone know about the mechanism between creatine and 5-alpha reductase?

7 upvotes 7 years ago

Creatine may raise DHT levels, potentially affecting hair loss, but its exact mechanism is unclear. Some users report that finasteride remains effective even when taking creatine.

community What blood results (if any) could be affected by Fin/Min?

in Finasteride/Dutasteride 2 upvotes 1 year ago

Finasteride can increase total testosterone and potentially raise estrogen levels, leading to side effects. Biotin in combined tablets can falsely elevate thyroid hormone levels in blood tests.

community What happens if you combine dutasteride and a aromataze inhibitor?

4 upvotes 7 years ago

Combining dutasteride and an aromatase inhibitor may increase testosterone levels significantly, potentially enhancing athletic performance but also posing health risks like elevated blood pressure and worsened cholesterol. The user is experimenting with dutasteride, anastrozole, minoxidil, and ketoconazole shampoo to manage hair loss and estradiol levels, while monitoring side effects and hormone levels.

community Fin raised my estrogen but also testosterone?

in Finasteride/Dutasteride 17 upvotes 2 years ago

A user experienced initial side effects from finasteride, including erectile dysfunction and emotional changes, but later noticed increased muscle mass and assertiveness. Hormonal tests showed elevated estrogen and prolactin levels, which slightly decreased over time; the user plans lifestyle changes to see if they help.

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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