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research Xinyang Tablet Ameliorates Sepsis-Induced Myocardial Dysfunction by Regulating Beclin-1 to Mediate Macrophage Autophagy and M2 Polarization Through LncSICRNT1 Targeting E3 Ubiquitin Ligase TRAF6

6 citations , November 2023 in “Chinese Medicine”

Xinyang Tablet improves heart function in sepsis by reducing inflammation.

research ADAM17 Variant Causes Hair Loss via Ubiquitin Ligase TRIM47 Mediated Degradation

May 2024 in “JCI insight”

A variant in the ADAM17 gene causes hair loss by increasing protein degradation through TRIM47.

research The Role of R-Spondins and Their Receptors in Bone Metabolism

25 citations , May 2016 in “Progress in Biophysics & Molecular Biology”

R-spondins and their receptors help increase bone growth and may be used to treat bone loss diseases.

research The Anti-Muscle Atrophy Effects of Ishige Sinicola in LPS-Induced C2C12 Myotubes Through Antioxidant and Anti-Inflammatory Actions

1 citations , September 2023 in “Applied sciences (Basel)”

Ishige sinicola extract may help prevent muscle atrophy through its antioxidant and anti-inflammatory effects.

research Protein Degradation: Expanding the Toolbox to Restrain Cancer Drug Resistance

7 citations , January 2023 in “Journal of Hematology & Oncology”

Using protein degradation to fight cancer drug resistance shows promise but needs more precise targeting and fewer side effects.

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community GT20029 China Phase II Trial For AGA Reached Primary Endpoint

in Research/Science 134 upvotes 1 year ago

The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.

community PYRILUTAMIDE PHASE 3 RESULTS : No statistical significance

in Research/Science 126 upvotes 2 years ago

The phase 3 trial results for Pyrilutamide showed no significant difference from the control treatment in increasing hair count, leading to the company halting its development. Users discussed their disappointment and skepticism about hair loss treatments, with some mentioning other treatments like Minoxidil, Finasteride, and RU58841.

community hair loss treatment alternatives and ideas to improve gain

in Treatment 3 upvotes 2 years ago

The post discusses using finasteride, minoxidil, ketoconazole, and a dermaroller for hair loss, along with spearmint capsules, pueraria mirifica, saw palmetto, biotin, and vitamins. The user is also considering microdosing finasteride with trans treatment and mentions the potential of herbal enemas and hair systems.

community How many mgs of zinc should I take while taking fin? I want to potentially offset side effects but not ruin the effectiveness of fin. I take .5 mg fin daily

in Chat 13 upvotes 4 years ago

A user asks about the appropriate zinc dosage to offset side effects while taking 0.5 mg of finasteride daily. Responses suggest zinc has a minor effect on hormones compared to finasteride.

community Forgotten Hair Loss Peptide by L'Oreal: KPV

in Research/Science 5 upvotes 1 year ago

KPV, a peptide patented by L'Oreal, may promote hair growth and reduce hair loss by extending the anagen phase and has anti-inflammatory properties. It could be combined with treatments like minoxidil for enhanced effects.

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